Oligonucleotide analogs with novel linkages
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United States of America Patent
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Nov 23, 1993
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app pub date -
Apr 24, 1991
filing date -
Oct 24, 1989
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Abstract
Oligonucleotide analogs wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by an formacetal/ketal type linkage are resistant to nucleases and do not need to exhibit the diastereomerism characteristic of many other oligonucleotide analogs, and thus are capable of strong hybridization to target RNA or DNA. These oligonucleotide analogs are useful in therapies which modulate gene expression using 'antisense' or other specifically binding oligomers.
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