US Patent No: 5,268,305

Number of patents in Portfolio can not be more than 2000

Multi-optical detection system

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Abstract

Apparatus and methods are provided for the detection of analytes. A polyunsaturated polymerized lipid layer is employed, which is anisotropic, has a member of a specific binding pair bound to an end of the lipids, and whose optical characteristics are modified upon complex formation between the specific binding pair member and its complementary member. By providing for polarized light, linear and/or circular, one can detect the presence of complex formation by the change in the optical characteristics of the film. Polarizers, analyzers, and wave plates are employed for providing for a light signal which can be analyzed and related to the presence of an analyte in a sample.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BIOCIRCUITS CORPORATIONSUNNYVALE, CA14

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choate, Glenda L Belmont, CA 5 132
Guion, Todd A Burlingame, CA 2 86
Murdoch, Joseph R Burlingame, CA 7 455
Pan, Victor Bedminster, NJ 8 183
Ribi, Hans O San Mateo, CA 56 1006
Scott, John C Los Gatos, CA 23 462

Cited Art

Patent Info (Count) # Cites Year
 
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BIOCIRCUITS, INC. A CORPORATION OF DELAWARE (1)
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DADE BEHRING MARBURG GMBH (1)
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IRT CORPORATION (1)
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Lundstroem; Kurt I. (1)
4,521,522 Optical specific binding assay with reflection of polarized electromagnetic radiation 38 1982
 
Mast Immunosystems, Ltd. (1)
4,558,013 Calibrated reaction measurement system 19 1983
 
Prutec Limited (1)
RE33064 Method for the determination of species in solution with an optical wave-guide 83 1987
 
WIECHMAN HAROLD CARL, M.D. (1)
4,621,063 Methods for the detection and quantitation of immunological substances 15 1982
 
Other [Check patent profile for assignment information] (1)
RE33581 Immunoassay using optical interference detection 82 1987

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (11)
6,001,556 Polymeric assay film for direct colorimetric detection 30 1996
6,183,772 Doped colorimetric assay liposomes 9 1996
6,017,390 Growth of oriented crystals at polymerized membranes 39 1997
6,103,217 Polymeric assemblies for sensitive colorimetric assays 12 1997
6,022,748 Sol-gel matrices for direct colorimetric detection of analytes 87 1997
6,180,135 Three-dimensional colorimetric assay assemblies 5 1997
6,080,423 Three dimensional colorimetric assay assemblies 13 1997
6,468,759 Direct colorimetric detection of biocatalysts 12 1998
6,395,561 Polymeric assay film for direct colorimetric detection 6 1999
6,485,987 Sol-gel matrices for direct colorimetric detection of analytes 7 2000
6,660,484 Colorimetric glycopolythiophene biosensors 15 2000
 
PLEXERA, LLC (5)
7,889,347 Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism 2 2006
8,094,315 Methods for making and using SPR microarrays 1 2008
8,004,669 SPR apparatus with a high performance fluid delivery system 2 2008
8,107,082 SPR apparatus with a high performance fluid delivery system 1 2011
8,325,346 SPR apparatus with a high performance fluid delivery system 0 2012
 
UNIVERSITAT ZURICH (5)
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7,132,475 Block copolymers for multifunctional self-assembled systems 2 2001
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7,670,605 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 2 2008
 
BIOCIRCUITS CORPORATION (4)
5,415,999 Fluorescent lipid polymer-macromolecular ligand compositions as detection element in ligand assays 20 1993
5,427,915 Multi-optical detection system 41 1993
5,618,735 Fluorescent lipid polymer-macromolecular ligand compositions 18 1995
5,622,872 Analyte detection through observed optical modulation of polymerized lipid layers 70 1995
 
Pence, Inc. (4)
6,130,037 Biosensor device and method 10 1997
5,955,379 Biosensor device and method 14 1997
6,478,939 Biosensor device and method 10 2000
6,461,490 Biosensor device and method 10 2000
 
UNIVERSITY OF UTAH (2)
5,814,565 Integrated optic waveguide immunosensor 40 1995
6,222,619 Diagnostic device and method 36 1997
 
FISO TECHNOLOGIES INC. (1)
7,897,406 Method and sensor for detecting a chemical substance using an optically anisotropic material 0 2003
 
FLUOROCAP LIMITED (1)
7,655,475 Luminescence based sensor using protuberances to redirect light 0 2002
 
HELIX BIOPHARMA CORPORATION (1)
6,787,368 Biosensor method for detecting analytes in a liquid 45 2000
 
Hinds Instruments, Inc. (1)
7,002,685 System for measuring of both circular and linear birefringence 4 2002
 
KUROS BIOSURGERY AG (1)
8,282,912 Compositions for tissue augmentation 0 2009
 
MCGILL UNIVERSITY (1)
6,107,080 Biosensor device and method 31 1997
 
ORBISPHERE LABORATORIES NEUCHATEL SA (1)
5,545,567 Luminoscopic analytic device and method 18 1995
 
SCIENCE & TECHNOLOGY CORPORATION @ UMN (1)
6,660,532 Modular assembly for reagentless affinity separation and detection of analyte 0 1999
 
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (1)
5,422,283 Solid-phase interferometric immunoassay system 3 1994
 
The Scripps Research Institute (1)
7,642,085 Protein arrays 9 2003
 
VANDERBILT UNIVERSITY (1)
8,134,707 On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes 0 2005
 
WILLIAM REBER, L.L.C. (1)
5,948,694 Molecular detection apparatus 3 1997
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (1)
7,807,348 Optical imaging of nanostructured substrates 1 2002
 
Other [Check patent profile for assignment information] (1)
8,034,634 Ultra-sensitive magnetoreduction measurement system and ultra-sensitive, wash-free assay using the same 0 2007