US Patent No: 5,268,305

Number of patents in Portfolio can not be more than 2000

Multi-optical detection system

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Abstract

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Apparatus and methods are provided for the detection of analytes. A polyunsaturated polymerized lipid layer is employed, which is anisotropic, has a member of a specific binding pair bound to an end of the lipids, and whose optical characteristics are modified upon complex formation between the specific binding pair member and its complementary member. By providing for polarized light, linear and/or circular, one can detect the presence of complex formation by the change in the optical characteristics of the film. Polarizers, analyzers, and wave plates are employed for providing for a light signal which can be analyzed and related to the presence of an analyte in a sample.

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First Claim

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Patent Owner(s)

  • BIOCIRCUITS CORPORATION

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choate, Glenda L Belmont, CA 5 164
Guion, Todd A Burlingame, CA 2 111
Murdoch, Joseph R Burlingame, CA 7 516
Pan, Victor Burlingame, CA 8 247
Ribi, Hans O San Mateo, CA 60 1320
Scott, John C Los Gatos, CA 22 584

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (8)
* 4,521,522 Optical specific binding assay with reflection of polarized electromagnetic radiation 40 1982
* 4,621,063 Methods for the detection and quantitation of immunological substances 15 1982
* 4,558,013 Calibrated reaction measurement system 19 1983
* 4,743,560 Solid phase assay 88 1984
* 4,661,442 Producing lipid-protein membranes for chemical detection 12 1984
* 4,859,538 Novel lipid-protein compositions and articles and methods for their preparation 43 1986
* RE33581 Immunoassay using optical interference detection 92 1987
* RE33064 Method for the determination of species in solution with an optical wave-guide 93 1987
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (84)
* 5,415,999 Fluorescent lipid polymer-macromolecular ligand compositions as detection element in ligand assays 20 1993
* 5,427,915 Multi-optical detection system 52 1993
* 5,422,283 Solid-phase interferometric immunoassay system 3 1994
* 5,814,565 Integrated optic waveguide immunosensor 46 1995
* 5,618,735 Fluorescent lipid polymer-macromolecular ligand compositions 18 1995
* 5,622,872 Analyte detection through observed optical modulation of polymerized lipid layers 87 1995
* 5,545,567 Luminoscopic analytic device and method 18 1995
* 6,001,556 Polymeric assay film for direct colorimetric detection 30 1996
* 6,183,772 Doped colorimetric assay liposomes 9 1996
* 5,948,694 Molecular detection apparatus 3 1997
* 6,130,037 Biosensor device and method 10 1997
* 6,107,080 Biosensor device and method 32 1997
* 5,955,379 Biosensor device and method 17 1997
* 6,017,390 Growth of oriented crystals at polymerized membranes 73 1997
* 6,103,217 Polymeric assemblies for sensitive colorimetric assays 12 1997
* 6,022,748 Sol-gel matrices for direct colorimetric detection of analytes 132 1997
6,222,619 Diagnostic device and method 66 1997
6,180,135 Three-dimensional colorimetric assay assemblies 6 1997
* 6,080,423 Three dimensional colorimetric assay assemblies 15 1997
* 6,468,759 Direct colorimetric detection of biocatalysts 14 1998
* 6,395,561 Polymeric assay film for direct colorimetric detection 6 1999
* 6,660,532 Modular assembly for reagentless affinity separation and detection of analyte 1 1999
7,744,912 Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups 15 2000
6,485,987 Sol-gel matrices for direct colorimetric detection of analytes 10 2000
6,787,368 Biosensor method for detecting analytes in a liquid 48 2000
6,478,939 Biosensor device and method 11 2000
6,461,490 Biosensor device and method 11 2000
6,660,484 Colorimetric glycopolythiophene biosensors 21 2000
* 2002/0031,449 Multiple-container systems with improved sensitivity for optical analysis 2 2001
7,291,673 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 15 2001
7,132,475 Block copolymers for multifunctional self-assembled systems 9 2001
* 2003/0059,906 Block copolymers for multifunctional self-assembled systems 5 2001
* 7,655,475 Luminescence based sensor using protuberances to redirect light 0 2002
* 2003/0179,692 Storage medium 10 2002
* 7,807,348 Optical imaging of nanostructured substrates 2 2002
* 2003/0044,468 Two-phase processing of thermosensitive polymers for use as biomaterials 22 2002
* 7,002,685 System for measuring of both circular and linear birefringence 5 2002
* 2003/0017,081 Method and apparatus for imaging a sample on a device 2 2002
* 2003/0129,618 Sensitive and rapid detection of pathogenic organisms and toxins using fluorescent polymeric lipids 10 2002
* 2003/0220,245 Conjugate addition reactions for the controlled delivery of pharmaceutical active compounds 18 2003
* 2004/0023,303 Method for evaluating drug candidates 1 2003
* 2003/0179,375 System for measuring of both circular and linear birefringence 0 2003
* 2004/0253,714 Thermal and fluidic cycling device for nucleic acid hybridization 5 2003
* 7,897,406 Method and sensor for detecting a chemical substance using an optically anisotropic material 2 2003
* 2006/0141,466 Method and sensor for detecting a chemical substance using an optically anisotropic material 8 2003
7,642,085 Protein arrays 11 2003
* 2004/0198,637 Protein arrays 92 2003
* 2004/0124,336 Luminescence based sensor 5 2004
* 2005/0281,708 Method and apparatus for imaging a sample on a device 3 2005
* 2005/0247,887 Method and apparatus for imaging a sample on a device 2 2005
* 2007/0172,813 Method for Evaluating Drug Candidates 0 2005
* 8,134,707 On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes 1 2005
* 2010/0027,008 On-Chip Polarimetry for High-Throughput Screening of Nanoliter and Smaller Sample Volumes 6 2005
7,413,739 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 9 2005
* 2006/0127,352 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 3 2005
* 2010/0222,407 TRIBLOCK COPOLYMERS FOR CYTOPLASMIC DELIVERY OF GENE-BASED DRUGS 2 2006
7,889,347 Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism 3 2006
* 8,034,634 Ultra-sensitive magnetoreduction measurement system and ultra-sensitive, wash-free assay using the same 1 2007
* 8,586,388 Molecular detection system 0 2007
* 2010/0053,619 MOLECULAR DETECTION SYSTEM 0 2007
* 2010/0247,223 STYLUS-SUBSTRATE SYSTEM FOR DIRECT IMAGING, DRAWING, AND RECORDING 3 2007
8,961,947 Polymeric tissue sealant 0 2008
* 2008/0253,987 POLYMERIC TISSUE SEALANT 6 2008
7,670,605 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 4 2008
8,094,315 Methods for making and using SPR microarrays 2 2008
8,004,669 SPR apparatus with a high performance fluid delivery system 3 2008
8,282,912 Compositions for tissue augmentation 1 2009
* 2011/0077,385 Protein arrays 0 2009
9,271,929 Block copolymers and uses thereof 0 2009
8,746,883 Ocular surface interferometery (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 2 2010
8,545,017 Ocular surface interferometry (OSI) methods for imaging, processing, and/or displaying an ocular tear film 4 2010
* 2010/0259,722 Ocular surface interferometry (OSI) methods for imaging, processing, and/or displaying an ocular tear film 0 2010
* 2010/0253,907 Ocular surface interferometery (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 11 2010
8,107,082 SPR apparatus with a high performance fluid delivery system 2 2011
8,591,033 Tear film measurement 5 2011
8,325,346 SPR apparatus with a high performance fluid delivery system 0 2012
8,585,204 Tear film measurement 5 2012
8,477,313 SPR apparatus with a high performance fluid delivery system 0 2012
8,915,592 Apparatuses and methods of ocular surface interferometry (OSI) employing polarization and subtraction for imaging, processing, and/or displaying an ocular tear film 2 2013
9,273,949 Backscattering interferometric methods 0 2013
8,888,286 Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography 2 2013
9,357,915 Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 0 2014
9,339,177 Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography 0 2014
9,180,222 Polymeric tissue sealant 0 2015
* Cited By Examiner