Methods for identifying nucleic acid ligands
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United States of America Patent
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Dec 14, 1993
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N/A
app pub date -
Aug 17, 1992
filing date -
Jun 11, 1990
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Abstract
The SELEX (Systematic Evolution of Ligands by EXponential Enrichment) method is disclosed for the identification of nucleic acid ligands. A candidate mixture of single stranded nucleic acids having regions of randomized sequence is contacted with a target compound and those nucleic acids having an increased affinity to the target are partitioned from the remainder of the candidate mixture. The partitioned nucleic acids are amplified to yield a ligand enriched mixture.
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