Method of diagnosis of amyloidoses

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United States of America Patent

PATENT NO 5270165
SERIAL NO

07779070

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of diagnosing a disease with cerebrovascular deposition of amyloid, including Alzheimer's disease, hereditary cerebral hemorrhage with amyloidosis-Dutch type and other amyloidoses, in a mammal is disclosed in which a sample of cerebrospinal fluid is obtained, the level of immunoreactivity toward a monoclonal antibody raised against native PN-2/.beta.APP or other amyloid precursor protein in the sample is measured, and this measured level is compared to the level of immunoreactivity toward this antibody in a sample from NOTICE OF GOVERNMENT SUPPORT This invention was made with Government support under Grant No. GM-31609 awarded by the National Institutes of Health. The Government has certain rights in this invention. American Cancer Society Grants CD 390 and BC 602/BE 22A provided further support for the development of this invention.

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  • REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cunningham, Dennis D Laguna Beach, CA 5 125
Van, Nostrand William E Irvine, CA 6 121
Wagner, Steven L La Jolla, CA 10 192

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