Penetration enhancers for transdermal delivery of systemic agents
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United States of America Patent
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Dec 14, 1993
Issued Date -
N/A
app pub date -
Nov 6, 1992
filing date -
Jan 31, 1986
priority date (Note) -
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Abstract
This invention relates to a method for administering systemically active agents, including therapeutic agents, through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent a non-toxic, effective, penetrating amount of a membrane penetration enhancer having the structural formula ##STR1## wherein X represents sulfur or two hydrogen atoms; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-18 and R is --CH.sub.3, ##STR2## wherein R' is H or halogen.
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