[(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates
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United States of America Patent
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Dec 28, 1993
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Mar 26, 1992
filing date -
Mar 26, 1992
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Abstract
This invention provides novel 2-substituted-3-quinuclidinyl arylcarboxamides and arylthiocarboxamides and corresponding arylcarboxylates which have utility as therapeutic agents which exhibit gastric prokinetic, antiemetic, anxiolytic and 5-HT (serotonin) antagonist effects in warm blooded animals. Illustrative of an invention compound is 5-chloro-2-methoxy-4-(methylamino)-N-[2-(1-piperidinylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzamide: ##STR1## or a pharmaceutically acceptable salt thereof.
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