Non-anticoagulant heparin derivatives

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United States of America Patent

PATENT NO 5280016
SERIAL NO

07753299

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Abstract

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A non-anticoagulant (NAC) form of heparin which shows antiproliferative activity with respect to smooth muscle cells is useful in the prevention of restenosis and other conditions benefited by antiproliferative activity with respect to smooth muscle cells. This NAC form of heparin is prepared by oxidizing heparin/heparan sulfate to a desired level with periodate followed by reduction of the resulting aldehyde groups; all under conditions which prevent depolymerization of the heparin.

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Patent Owner(s)

Patent OwnerAddress
GLYCOMED INCORPORATED860 ATLANTIC AVENUE ALAMEDA CA 94501

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Conrad, H Edward Alameda, CA 4 141
Guo, Yuchuan Alameda, CA 2 74

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