Isolated, large latent complexes of TGF-.beta.2 and TGF-.beta.3, and new binding protein for latent form TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3 LTBP-2

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United States of America Patent

PATENT NO 5280109
SERIAL NO

07826577

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Abstract

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The invention relates to large latent complexes of TGF-.beta.2 and TGF-.beta.3, and methods for Isolating these. The complex consists of a dimerized form of TGF-.beta.2 or TGF-.beta.3, the appropriate latency associated peptide, and the latent TGF-.beta.1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3, but is immunologically distinct from LTBP, referred to as LTBP-2.

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Patent Owner(s)

Patent OwnerAddress
LUDWIG INSTITUTE FOR CANCER RESEARCH605 THIRD AVENUE 33RD FLOOR NEW YORK NEW YORK 10158 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Heldin, Carl-Henrik Uppsala, SE 49 444
Miyazono, Kohei Uppsala, SE 38 359
Olofsson, Anders Uppsala, SE 8 86

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