N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them
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United States of America Patent
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Jan 25, 1994
Grant Date -
N/A
app pub date -
May 23, 1991
filing date -
May 23, 1990
priority date (Note) -
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Abstract
New N-substituted 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines useful in the treatment of intestinal motility disorders, of the following general formula ##STR1## wherein A represents a group --E--G or --L--M, where --E-- is a straight or branched alkylene radical of from 2 to 4 carbon atoms, --G represents a radical selected from the group consisting of naphthyl mono-substituted with hydroxy or (C.sub.1 -C.sub.4)alkoxy; naphthyl di-substituted with hydroxy, (C.sub.1 -C.sub.4)alkoxy or (C.sub.1 -C.sub.4)alkyl; or naphthyl substituted with methylenedioxy, --L-- is a --Q--CH(OH)-- group wherein --Q-- is a straight or branched alkylene radical of from 1 to 3 carbon atoms, and --M represents a radical selected from the group consisting of naphthyl; naphthyl mono- or di-substituted with hydroxy, (C.sub.1 -C.sub.4)alkoxy or (C.sub.1 -C.sub.4)alkyl or naphthyl substituted with methylenedioxy; pyridyl; or (C.sub.1 -C.sub.4)alkyl-pyridyl, and their salts with mineral or organic acids.
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