Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
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United States of America Patent
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Feb 1, 1994
Issued Date -
N/A
app pub date -
Nov 13, 1992
filing date -
Sep 23, 1991
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Abstract
Taxane derivatives of the formula ##STR1## wherein R.sub.1 is phenyl or p-nitrophenyl, R.sub.3 is furyl or thienyl, T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or monocylic aryl, Ac is acetyl, and E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
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