4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5284971
SERIAL NO

07914837

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds of general formula (I) ##STR1## wherein R.sup.1 is (CH.sub.2).sub.n ((CHNR.sup.7 R.sup.8).sub.m C(O)R.sup.9 ; n=1-3; and m=0 or 1; R.sup.3 and R.sup.5 are independently Cl, Br, I, or CH.sub.3 ; R.sup.7 and R.sup.8 are independently H or (C.sub.1 -C.sub.4)alkyl; R.sup.9 is OH, (C.sub.1 -C.sub.4)alkoxy, or NR.sup.7 R.sup.8 ; R.sup.31 is H, Cl, Br, I, (C.sub.1 -C.sub.4)alkyl, (C.sub.4 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.4)haloalkyl, (C.sub.4 -C.sub.6)halocycloalkyl, or --CH(R.sup.10)Ar where Ar is selected from 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methoxypyridazin-3-yl, 6-hydroxypyridazin-3-yl N-oxide, and 6-methoxypyridazin-3-yl N-oxide and R.sup.10 is H or (C.sub.1 -C.sub.4)alkyl; R.sup.41 is OH or a bioprecursor thereof; and the pharmaceutically acceptable salts thereof; are structural analogs of the thyroid hormones T.sub.3 and T.sub.4 and exhibit selective thyromimetic activity. Pharmaceutical compositions of the novel compounds and their use for the treatment of mammalian cholesteremia are provided.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SYNTEX (U.S.A.) INC.PALO ALTO, CA35

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kertesz, Denis J Mountain View, CA 13 64
Labadie, Sharada S Sunnyvale, CA 5 48
Laughton, Craig W Palo Alto, CA 1 34
Walker, Keith A Los Altos Hills, CA 23 299

Cited Art Landscape

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Patent Citation Ranking

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