4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents

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United States of America Patent

PATENT NO 5284971
SERIAL NO

07914837

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds of general formula (I) ##STR1## wherein R.sup.1 is (CH.sub.2).sub.n ((CHNR.sup.7 R.sup.8).sub.m C(O)R.sup.9 ; n=1-3; and m=0 or 1; R.sup.3 and R.sup.5 are independently Cl, Br, I, or CH.sub.3 ; R.sup.7 and R.sup.8 are independently H or (C.sub.1 -C.sub.4)alkyl; R.sup.9 is OH, (C.sub.1 -C.sub.4)alkoxy, or NR.sup.7 R.sup.8 ; R.sup.31 is H, Cl, Br, I, (C.sub.1 -C.sub.4)alkyl, (C.sub.4 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.4)haloalkyl, (C.sub.4 -C.sub.6)halocycloalkyl, or --CH(R.sup.10)Ar where Ar is selected from 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methoxypyridazin-3-yl, 6-hydroxypyridazin-3-yl N-oxide, and 6-methoxypyridazin-3-yl N-oxide and R.sup.10 is H or (C.sub.1 -C.sub.4)alkyl; R.sup.41 is OH or a bioprecursor thereof; and the pharmaceutically acceptable salts thereof; are structural analogs of the thyroid hormones T.sub.3 and T.sub.4 and exhibit selective thyromimetic activity. Pharmaceutical compositions of the novel compounds and their use for the treatment of mammalian cholesteremia are provided.

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Patent Owner(s)

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SYNTEX (U S A ) INC3401 HILLVIEW AVENUE P O BOX 10850 A CORP OF DE PALO ALTO CA 94303

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kertesz, Denis J Mountain View, CA 13 67
Labadie, Sharada S Sunnyvale, CA 5 61
Laughton, Craig W Palo Alto, CA 1 35
Walker, Keith A Los Altos Hills, CA 27 339

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