Stabilized controlled release formulations having acrylic polymer coating
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United States of America Patent
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Feb 15, 1994
Grant Date -
N/A
app pub date -
Jan 27, 1992
filing date -
Jan 27, 1992
priority date (Note) -
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Abstract
A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of an acrylic polymer is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of the plasticized acrylic polymer and then curing the coated substrate at a temperature above the glass transition temperature of the plasticized acrylic polymer, until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.
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