Mammalian artificial chromosomes

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United States of America Patent

PATENT NO 5288625
SERIAL NO

07759558

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Abstract

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Non-human cell lines are disclosed which contain functional centromeres comprising human DNA sequences linked to a dominant marker gene. The centromeres are carried on stable chromosomes which carry no centromeres other than those comprising human DNA sequences. The cell lines can be used to isolate the chromosomes as well as for use in inserting genes into mammalian cells. Methods are taught for generating such cell lines from cell lines carrying dicentric chromosomes.

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Patent Owner(s)

Patent OwnerAddress
BIOLOGICAL RESEARCH CENTER OF THE HUNGARIAN ACADEMY OF SCIENCESH-6701 SZEGED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hadlaczky, Gyula Szamos, HU 20 576

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