Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
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United States of America Patent
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Mar 8, 1994
Issued Date -
N/A
app pub date -
Jan 30, 1992
filing date -
Sep 11, 1990
priority date (Note) -
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Abstract
The present invention provides a method for the production of medicinal aerosol compositions which are made up of a homogenous solution of aerosol propellants, a surfactant and a pharmaceutically active compound, where the process comprises purifying the surfactant, removing the water from the surfactant, and dispersing the surfactant in an aerosol propellant with a hydrophilic pharmaceutical composition and a controlled amount of water. The present invention also provides medicinal aerosol compositions produced by this method which are a homogenous solution of the pharmaceutically active compound contained in reverse micelles made up of the surfactant; and methods of using the medicinal aerosols to provide an effective amount of a therapeutic agent.
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