Method for controlling o-desulfation of heparin and compositions produced thereby
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United States of America Patent
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Mar 22, 1994
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N/A
app pub date -
Dec 22, 1992
filing date -
Dec 22, 1992
priority date (Note) -
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Abstract
Methods of making and using, as prophylatics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated including about 99% and 75% desulfated at the 2-O and 3-O positions, respectively.
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