Calcification-resistant synthetic biomaterials
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United States of America Patent
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Mar 22, 1994
Grant Date -
N/A
app pub date -
Jul 9, 1992
filing date -
Jul 9, 1992
priority date (Note) -
Expired
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Abstract
Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane and/or polydimethylsiloxane, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Illustratively, reaction conditions utilizing bi- or polyfunctional epoxides result in epoxide bridge incorporation of the anticalcification agent to the biomaterial elastomer.
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