US Patent No: 5,302,509

Number of patents in Portfolio can not be more than 2000

Method for sequencing polynucleotides

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Abstract

A method is provided for determining the sequence of nucleotides on a single strand DNA molecule. The single strand DNA molecule is attached to a leader oligonucleotide and its complementary strand to a solid state support. Fluorescently-labeled 3'-blocked nucleotide triphosphates, with each of the bases A, G, C, T having a different fluorescent label, are mixed with the bound DNA molecule in the presence of DNA polymerase. The DNA polymerase causes selective addition of only the complementary labeled NTP, thus identifying the next unpaired base in the unknown DNA strand. The 3'-blocking group is then removed, setting the system up for the next NTP addition and so on. The sequence is repeated until no more fluorescently-labeled NTPs can be detected as being added by the polymerase.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BECKMAN INSTRUMENTS, INC.FULLERTON, CA535

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheeseman, Peter C Palo Alto, CA 1 279

Cited Art

Patent Info (Count) # Cites Year
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
5,001,051 Dose critical in-vivo detection of anti-cancer drug levels in blood 37 1986

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
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