A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
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United States of America Patent
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Apr 19, 1994
Grant Date -
N/A
app pub date -
Jun 11, 1991
filing date -
Jun 11, 1991
priority date (Note) -
Expired
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Abstract
The instant invention provides novel molecules derived from the components of proinsulin using recombinant DNA technology. The invention provides molecules of the formula A--C--B wherein A is the A-chain of an insulin species, B is the B-chain of an insulin species and C is a connecting peptide. These molecules possess insulin-like activity and are useful for the treatment of diabetes mellitus, particularly non-insulin dependent diabetes mellitus. These molecules are also useful for the production of insulin and constitute a novel pathway for the recombinant production of insulin species. The invention provides a method of making insulin proceeding through the compounds of the invention as intermediates. The instant invention further provides recombinant DNA compounds which encode the compounds of the invention.
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