Antigen specifically expressed on the surface of B cells and Hodgkin's cells
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United States of America Patent
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Apr 19, 1994
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app pub date -
Dec 16, 1992
filing date -
Mar 12, 1990
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Abstract
The invention relates to a new antigen termed BLA-35 specifically expressed on the surface of Hodgkin's cells, Reed-Sternberg cells and B lymphocytes, and to a new monoclonal antibody (anti-BLA-36) specific thereto. The antigen is characterized by the following properties: a molecular weight of about 36,000 D; the presence of an epitope recognized by antibody to said protein; specific expression by Hodgkin's cells and Reed-Sternberg cells in all subsets of Hodgkin's disease, and by activated and early proliferating B cells; no expression by T cells; capability of reacting with its antibody in both frozen and fixed/paraffin embedded tissues; a function associated with the growth of cells capable to express said antigen protein.
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