US Patent No: 5,306,304

Number of patents in Portfolio can not be more than 2000

Flexible membranes produced from organic bone matrix for skeletal repair and reconstruction

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Abstract

A flexible, organic bone matrix which is adapted for use during the in vivo repair, replacement or reformation of preselected portions of a mammalian or animal skeletal system comprising a continuous sheet of completely or partially demineralized natural bone, wherein the thickness of said sheet is such that the sheet has sufficient flexibility to allow the sheet to be shaped to conform to the configuration of a skeletal region to be repaired and sufficient tensile strength to allow the sheet to be so shaped without damage to the sheet. The matrix is ultimately resorbed by the body thereby eliminating the need for supplemental surgery to remove the matrix, as is presently necessary when other exogenous, membrane materials are used. A method f or the in vivo repair or replacement of a preselected section of a mammalian or animal skeletal system utilizing said matrix is also disclosed.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
GENDLER, EL AND GENDLER, SIMONA, TRUSTEES OF THE GENDLER LIVING TRUST ESTABLISHED DECEMBER 24, 1992SANTA MONICA, CA5
GENDLER FAMILY LIMITED PARTNERSHIPSANTA MONICA, CA7

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gendler, El 415 Georgina Ave., Santa Monica, CA 90402 8 496

Cited Art

Patent Info (Count) # Cites Year
 
BAXTER INTERNATIONAL INC. (1)
5,053,049 Flexible prostheses of predetermined shapes and process for making same 107 1985
 
GENSCI ORTHOBIOLOGICS, INC. (1)
4,472,840 Method of inducing osseous formation by implanting bone graft material 205 1982

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
APERION BIOLOGICS, INC. (19)
5,865,849 Meniscal heterografts 39 1995
5,782,915 Articular cartilage heterografts 44 1997
5,913,900 Substantially native meniscal cartilage heterografts 21 1997
5,922,027 Articular cartilage heterografts 33 1997
6,093,204 Meniscal heterografts 43 1998
6,210,440 Anterior cruciate ligament xenografts 4 1998
6,110,206 Anterior cruciate ligament xenografts 13 1998
6,049,025 Articular cartilage xenografts 28 1998
6,046,379 Meniscal xenografts 49 1998
5,984,858 Meniscal xenografts 20 1998
5,944,755 Articular cartilage xenografts 31 1998
6,267,786 Proteoglycan-reduced soft tissue xenografts 27 1999
6,231,608 Aldehyde and glycosidase-treated soft and bone tissue xenografts 34 1999
6,972,041 Bone xenografts 1 1999
6,383,732 Method of preparing xenograft heart valves 20 2000
6,402,783 Anterior cruciate ligament xenografts 2 2000
6,455,309 Proteoglycan-reduced soft tissue xenografts 12 2001
7,722,672 Bone xenografts 0 2002
7,645,568 Xenograft heart valves 0 2004
 
WARSAW ORTHOPEDIC, INC. (15)
5,507,813 Shaped materials derived from elongate bone particles 240 1993
5,439,684 Shaped, swollen demineralized bone and its use in bone repair 197 1994
5,676,146 Surgical implant containing a resorbable radiopaque marker and method of locating such within a body 127 1996
5,899,939 Bone-derived implant for load-supporting applications 262 1998
6,123,731 Osteoimplant and method for its manufacture 159 1998
6,436,138 Process for producing flexible sheets from demineralized, elongate, bone particles 17 1998
6,294,041 Method for an osteoimplant manufacture 89 1999
6,843,807 Osteoimplant 16 2000
7,833,255 Bone fasteners and method for stabilizing vertebral bone facets using the bone fasteners 3 2002
7,252,685 Fusion implant and method of making same 2 2003
8,268,008 Osteoimplants and methods for their manufacture 0 2006
7,959,941 Bone graft comprising a demineralized bone matrix and a stabilizing agent 0 2007
7,939,108 Method of making demineralized bone particles 0 2007
8,002,813 Volume maintaining osteoinductive/osteoconductive compositions 0 2009
8,197,474 Volume maintaining osteoinductive/osteoconductive compositions 0 2011
 
WRIGHT MEDICAL TECHNOLOGY, INC. (10)
7,371,408 Bone graft substitute composition 2 1999
7,371,409 Bone graft substitute composition 1 2001
7,371,410 Bone graft substitute composition 1 2002
6,652,887 Bone graft substitute composition 15 2002
7,211,266 Bone graft substitute composition 2 2003
7,291,179 Bone graft substitute composition 1 2003
7,507,257 Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects 0 2004
7,250,550 Synthetic bone substitute material 10 2004
7,766,972 Synthetic, malleable bone graft substitute material 0 2007
7,658,768 Bone graft substitute composition 8 2007
 
MUSCULOSKELETAL TRANSPLANT FOUNDATION (9)
6,998,135 Demineralized corticocancellous bone sheet 0 2001
7,901,457 Cartilage allograft plug 6 2003
7,815,926 Implant for articular cartilage repair 2 2006
7,837,740 Two piece cancellous construct for cartilage repair 4 2007
RE42208 Glue for cartilage repair 3 2008
8,221,500 Cartilage allograft plug 0 2008
8,435,551 Cancellous construct with support ring for repair of osteochondral defects 0 2009
RE43258 Glue for cartilage repair 0 2010
8,292,968 Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 0 2011
 
SYNTHES USA, LLC (7)
6,986,788 Intervertebral allograft spacer 24 2001
6,855,169 Demineralized bone-derived implants 19 2001
6,776,800 Implants formed with demineralized bone 21 2001
6,652,593 Demineralized bone implants 20 2001
7,608,113 Demineralized bone implants 9 2003
7,300,465 Intervertebral allograft spacer 5 2005
7,753,963 Demineralized bone-derived implants 0 2008
 
GENDLER FAMILY LIMITED PARTNERSHIP (3)
5,464,439 Flexible membranes produced from organic bone matrix for skeletal repair and reconstruction 112 1993
5,904,716 Method for reconstituting cartilage tissue using demineralized bone and product thereof 50 1995
6,576,249 Bone putty and method 19 2000
 
METHODIST HOSPITAL OF INDIANA, INC. (3)
5,755,791 Perforated submucosal tissue graft constructs 137 1996
5,955,110 Multilayered submucosal graft constructs and method for making the same 107 1996
5,997,575 Perforated submucosal tissue graft constructs 77 1997
 
AGNOVOS HEALTHCARE, LLC (2)
7,754,246 Composite bone graft substitute cement and articles produced therefrom 1 2006
8,025,903 Composite bone graft substitute cement and articles produced therefrom 0 2007
 
APERION BIOLOGICS, IINC. (2)
5,902,338 Anterior cruciate ligament heterograft 30 1995
6,063,120 Anterior cruciate ligament heterograft 6 1998
 
ISOTIS ORTHOBIOLOGICS, INC. (2)
7,241,813 End-capped polymers and compositions containing such compounds 0 2002
7,205,337 End-capped polymers and compositions containing such compounds 0 2003
 
CLARIAN HEALTH PARTNERS, INC. (1)
5,968,096 Method of repairing perforated submucosal tissue graft constructs 72 1997
 
MACROPORE BIOSURGERY, INC. (1)
6,712,851 Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration 32 2001
 
MACROPORE, INC. (1)
5,919,234 Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration 47 1996
 
OSPREY BIOMEDICAL, INC. (1)
8,043,377 Implantable intervertebral fusion device 0 2006
 
TUTOGEN MEDICAL GMBH (1)
6,379,385 Implant of bone matter 43 2000
 
Other [Check patent profile for assignment information] (3)
5,868,749 Fixation devices 96 1997
5,968,047 Fixation devices 246 1998
7,837,707 Internal procedure for closing sinus membrane perforations 1 2007