Biocompatibility of solid surfaces
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United States of America Patent
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May 3, 1994
Grant Date -
N/A
app pub date -
Jan 19, 1993
filing date -
Jan 19, 1993
priority date (Note) -
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Abstract
An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylizine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
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