Substituted-5-methylidene hydantoins with AT.sub.1 receptor antagonist properties
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United States of America Patent
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May 3, 1994
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Nov 19, 1992
filing date -
Dec 20, 1991
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Abstract
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and method of using them. Intermediates useful in the preparation of the compounds of the invention are also disclosed and synthetic methods for preparing the novel intermediates. The compounds are useful as antagonists of angiotensin II and thus are useful in the control of hypertension, hyperaldosteronism, congestive heart failure, surgically induced vascular smooth muscle proliferation, and glaucoma.
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