Importance

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Abstract

Described is a device for the controlled release and delivery to mammalian tissue of a pharmacologically active agent comprising: (i) an impermeable backing member; (ii) a control membrane lamina consisting essentially of a first polymeric composition of matter which consists essentially of at least one C.sub.2 -C.sub.4 lower olefin-C.sub.1 -C.sub.8 alkyl acrylate and/or methacrylate copolymer having 2-90% by weight of alkyl acrylate and/or methacrylate monomeric units, taken alone, or taken further together with in intimate admixture, a second polymeric composition consisting essentially of a C.sub.2 -C.sub.4 polyalkylene corresponding to the C.sub.2 -C.sub.4 lower alkylene of said copolymer, said second polymeric composition being compatible with said first polymeric composition of matter; and (iii) a pharmacologically active agent reservoir maintained there between comprising said pharmacologically active agent and a carrier therefor and, optionally, one or more excipients and/or enhancers; and (iv) means for maintaining said device in pharmacologically active agent transmitting relationship to the mammalian tissue to be treated.

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First Claim