Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
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United States of America Patent
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May 17, 1994
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Oct 13, 1992
filing date -
Nov 22, 1989
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Abstract
Hemoglobin-containing solutions containing polyalkylene oxide-conjugated hemoglobin having a molecular weight greater than about 85,000 daltons and a degree of substitution of at least five polyalkylene oxide conjugates per hemoglobin molecule are described that are not associated with hemoglobinuria in mammals. A method of simultaneously fractionating and purifying polyalkylene oxide-conjugated hemoglobins is also disclosed.
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