US Patent No: 5,314,476

Number of patents in Portfolio can not be more than 2000

Demineralized bone particles and flowable osteogenic composition containing same

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Importance

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Abstract

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Demineralized bone particles having a median length to median thickness ratio of at least about 10:1 are incorporated in an osteogenic composition useful for repairing bone defects.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
OSTEOTECH INVESTMENT CORPORATIONSHREWSBURY, NJ11
WARSAW ORTHOPEDIC, INC.WARSAW, IN1651

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Prewett, Annamarie B Little Silver, NJ 9 1179
Stikeleather, Roger C Doylestown, PA 7 806

Cited Art Landscape

Patent Info (Count) # Cites Year
 
BAXTER INTERNATIONAL INC. (1)
* 5,053,049 Flexible prostheses of predetermined shapes and process for making same 128 1985
 
GENDLER FAMILY LIMITED PARTNERSHIP (1)
* 4,932,973 Cartilage and bone induction by artificially perforated organic bone matrix 153 1988
 
GENSCI ORTHOBIOLOGICS, INC. (1)
* 4,472,840 Method of inducing osseous formation by implanting bone graft material 242 1982
 
OSTEOTECH INVESTMENT CORPORATION (1)
* 5,073,373 Flowable demineralized bone powder composition and its use in bone repair 203 1989
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
WARSAW ORTHOPEDIC, INC. (51)
* 5,507,813 Shaped materials derived from elongate bone particles 296 1993
* 5,899,939 Bone-derived implant for load-supporting applications 314 1998
* 6,123,731 Osteoimplant and method for its manufacture 189 1998
6,436,138 Process for producing flexible sheets from demineralized, elongate, bone particles 26 1998
* 6,294,187 Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same 205 1999
6,294,041 Method for an osteoimplant manufacture 109 1999
6,843,807 Osteoimplant 31 2000
7,726,319 Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization 2 2000
6,638,310 Intervertebral spacer and implant insertion instrumentation 40 2000
* 6,616,698 Bone graft and guided bone regeneration method 37 2001
6,855,167 Spinal intervertebral implant, interconnections for such implant and processes for making 54 2001
8,758,438 Implant for orthopedic applications 0 2001
* 7,323,193 Method of making demineralized bone particles 10 2001
* 6,696,073 Shaped load-bearing osteoimplant and methods of making same 213 2002
7,163,691 Bone graft 36 2002
7,833,255 Bone fasteners and method for stabilizing vertebral bone facets using the bone fasteners 7 2002
7,662,185 Intervertebral implants 6 2003
8,133,421 Methods of making shaped load-bearing osteoimplant 1 2003
7,413,576 Biocompatible osteogenic band for repair of spinal disorders 17 2004
7,726,002 Processes for making spinal intervertebral implant, interconnections for such implant 0 2004
8,740,987 Tissue-derived mesh for orthopedic regeneration 0 2004
8,328,876 Bone matrix compositions and methods 0 2004
8,333,985 Non-glycerol stabilized bone graft 0 2005
7,780,708 Implant retaining device 7 2005
8,663,672 Osteoimplant and method of making same 0 2005
7,838,022 Malleable implants containing demineralized bone matrix 2 2006
7,771,741 Demineralized bone matrix devices 4 2006
8,268,008 Osteoimplants and methods for their manufacture 1 2006
7,959,941 Bone graft comprising a demineralized bone matrix and a stabilizing agent 5 2007
8,545,864 Hemostatic bone graft 0 2007
7,939,108 Method of making demineralized bone particles 1 2007
8,372,157 Joint revision implant 0 2008
8,039,016 Malleable implants containing demineralized bone matrix 2 2008
8,840,913 Malleable multi-component implants and materials therefor 0 2008
8,734,525 Osteoinductive demineralized cancellous bone 0 2008
8,642,061 Method of treating bone tissue 0 2008
8,357,384 Bone matrix compositions and methods 0 2008
7,799,076 Biocompatible osteogenic band for repair of spinal disorders 18 2008
8,202,539 Demineralized bone matrix compositions and methods 0 2008
8,002,813 Volume maintaining osteoinductive/osteoconductive compositions 2 2009
8,722,075 Compositions and methods for promoting bone formation 0 2009
8,431,147 Malleable implants containing demineralized bone matrix 1 2010
8,506,983 Bone filler material 0 2010
8,282,953 Malleable implants containing demineralized bone matrix 1 2010
8,672,980 Implant retaining device 0 2010
8,252,056 Biocompatible osteogenic band for repair of spinal disorders 0 2010
8,672,985 Bone fasteners and method for stabilizing vertebral bone facets using the bone fasteners 0 2010
8,529,962 Method of making demineralized bone particles 0 2011
8,197,474 Volume maintaining osteoinductive/osteoconductive compositions 1 2011
8,435,566 Demineralized bone matrix compositions and methods 0 2012
8,753,689 Method of making demineralized bone particles 0 2013
 
GMEDELAWARE 2 LLC (25)
8,163,017 Facet arthroplasty devices and methods 0 2003
8,092,532 Facet arthroplasty devices and methods 0 2003
8,070,811 Facet arthroplasty devices and methods 0 2003
8,066,771 Facet arthroplasty devices and methods 0 2003
7,087,084 Method for replacing a natural facet joint with a prosthesis having an artificial facet joint structure 133 2003
8,187,303 Anti-rotation fixation element for spinal prostheses 0 2004
7,691,145 Prostheses, systems and methods for replacement of natural facet joints with artificial facet joint surfaces 15 2004
7,608,104 Prostheses, tools and methods for replacement of natural facet joints with artifical facet joint surfaces 8 2004
7,674,293 Crossbar spinal prosthesis having a modular design and related implantation methods 31 2005
8,398,681 Adjacent level facet arthroplasty devices, spine stabilization systems, and methods 1 2005
7,406,775 Implantable orthopedic device component selection instrument and methods 44 2005
8,066,740 Facet joint prostheses 0 2005
8,221,461 Crossbar spinal prosthesis having a modular design and systems for treating spinal pathologies 0 2005
8,523,907 Prostheses, tools and methods for replacement of natural facet joints with artificial facet joint surfaces 0 2006
7,608,106 Facet arthroplasty devices and methods 8 2006
7,290,347 Facet joint prosthesis measurement and implant tools 32 2006
8,231,655 Prostheses and methods for replacement of natural facet joints with artificial facet joint surfaces 1 2006
7,914,556 Arthroplasty revision system and method 0 2006
8,496,686 Minimally invasive spine restoration systems, devices, methods and kits 0 2007
8,702,755 Angled washer polyaxial connection for dynamic spine prosthesis 0 2007
8,491,635 Crossbar spinal prosthesis having a modular design and related implantation methods 0 2007
8,425,557 Crossbar spinal prosthesis having a modular design and related implantation methods 1 2007
8,496,687 Crossbar spinal prosthesis having a modular design and related implantation methods 0 2007
8,409,254 Prostheses, tools and methods for replacement of natural facet joints with artificial facet joint surfaces 0 2008
8,675,930 Implantable orthopedic device component selection instrument and methods 0 2008
 
MUSCULOSKELETAL TRANSPLANT FOUNDATION (23)
* 6,030,635 Malleable paste for filling bone defects 129 1998
6,326,018 Flexible sheet of demineralized bone 51 1999
* 6,437,018 Malleable paste with high molecular weight buffered carrier for filling bone defects 74 2000
6,458,375 Malleable paste with allograft bone reinforcement for filling bone defects 83 2000
6,432,436 Partially demineralized cortical bone constructs 41 2000
6,911,212 Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects 62 2001
* RE38522 Malleable paste for filling bone defects 32 2002
* 6,548,080 Method for partially demineralized cortical bone constructs 3 2002
7,045,141 Allograft bone composition having a gelatin binder 41 2002
7,019,192 Composition for filling bone defects 19 2002
7,067,123 Glue for cartilage repair 21 2003
7,901,457 Cartilage allograft plug 22 2003
RE39587 Malleable paste for filling bone defects 20 2004
7,488,348 Cartilage allograft plug 21 2005
7,879,103 Vertebral disc repair 2 2006
7,815,926 Implant for articular cartilage repair 5 2006
* 7,837,740 Two piece cancellous construct for cartilage repair 12 2007
RE42208 Glue for cartilage repair 13 2008
8,221,500 Cartilage allograft plug 2 2008
8,435,551 Cancellous construct with support ring for repair of osteochondral defects 0 2009
8,906,110 Two piece cancellous construct for cartilage repair 0 2010
RE43258 Glue for cartilage repair 1 2010
8,292,968 Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 2 2011
 
SYNTHES USA, LLC (14)
6,660,038 Skeletal reconstruction cages 115 2001
6,986,788 Intervertebral allograft spacer 43 2001
* 6,855,169 Demineralized bone-derived implants 32 2001
6,776,800 Implants formed with demineralized bone 29 2001
7,608,113 Demineralized bone implants 11 2003
7,014,659 Skeletal reconstruction cages 17 2003
7,232,464 Intervertebral implant 53 2004
7,226,482 Multipiece allograft implant 17 2004
7,300,465 Intervertebral allograft spacer 14 2005
7,846,207 Intervertebral implant 19 2005
7,601,173 Multipiece allograft implant 15 2007
7,618,456 Intervertebral implant 27 2007
7,753,963 Demineralized bone-derived implants 6 2008
7,862,616 Intervertebral implant 23 2009
 
WRIGHT MEDICAL TECHNOLOGY, INC. (11)
7,371,408 Bone graft substitute composition 3 1999
7,371,409 Bone graft substitute composition 3 2001
7,371,410 Bone graft substitute composition 2 2002
6,652,887 Bone graft substitute composition 21 2002
7,211,266 Bone graft substitute composition 2 2003
7,291,179 Bone graft substitute composition 2 2003
7,507,257 Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects 0 2004
7,250,550 Synthetic bone substitute material 22 2004
8,657,952 Bone graft substitute composition 0 2007
7,766,972 Synthetic, malleable bone graft substitute material 0 2007
7,658,768 Bone graft substitute composition 9 2007
 
NUORTHO SURGICAL, INC. (9)
7,771,422 Methods and devices for electrosurgery 17 2004
7,819,861 Methods for electrosurgical electrolysis 7 2004
7,445,619 Devices for electrosurgery 14 2005
7,955,296 Biologically enhanced irrigants 1 2006
7,713,269 Devices for electrosurgery 7 2008
7,819,864 Electrosurgery devices 7 2009
8,591,508 Electrosurgical plenum 0 2009
8,235,979 Interfacing media manipulation with non-ablation radiofrequency energy system and method 0 2010
8,734,441 Interfacing media manipulation with non-ablation radiofrequency energy system and method 0 2010
 
BIOMET MANUFACTURING, LLC (6)
* 5,674,224 Bone mulch screw assembly for endosteal fixation of soft tissue grafts and method for using same 129 1994
6,565,884 Bone graft material incorporating demineralized bone matrix and lipids 18 2001
7,357,947 Bone graft material incorporating demineralized bone matrix and lipids 2 2003
7,678,385 Irradiated implantable bone material 1 2004
7,670,384 Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone 10 2006
7,976,861 Irradiated implantable bone material 1 2010
 
ORTHOCON, INC. (6)
8,105,628 Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects 1 2004
7,989,000 Absorbable putty-like implants and methods for their use for mechanical hemostasis of bone and for the treatment of osseous defects 0 2004
7,955,616 Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects 2 2005
8,603,528 Compositions and method for the reduction of post-operative pain 0 2006
8,337,879 Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects 0 2011
8,309,131 Absorbable putty-like implants and methods for their use for mechanical hemostasis of bone and for the treatment of osseous defects 0 2011
 
KENSEY NASH BVF TECHNOLOGY, LLC (5)
8,623,094 Devices and methods for treating defects in the tissue of a living being 0 2007
8,435,306 Devices and methods for treating defects in the tissue of a living being 0 2010
8,425,619 Devices and methods for treating defects in the tissue of a living being 0 2010
8,419,802 Devices and methods for treating defects in the tissue of a living being 1 2011
8,163,032 Devices and methods for treating defects in the tissue of a living being 2 2011
 
ZIMMER ORTHOBIOLOGICS, INC. (5)
6,679,918 Implantable putty material 27 1998
8,497,236 Implantable putty material 2 2008
8,742,072 Bone growth particles and osteoinductive composition thereof 0 2010
8,690,874 Composition and process for bone growth and repair 0 2010
8,613,938 Bone void fillers 0 2011
 
AGNOVOS HEALTHCARE, LLC (4)
7,754,246 Composite bone graft substitute cement and articles produced therefrom 4 2006
8,685,464 Composite bone graft substitute cement and articles produced therefrom 0 2007
8,025,903 Composite bone graft substitute cement and articles produced therefrom 1 2007
8,685,465 Composite bone graft substitute cement and articles produced therefrom 0 2011
 
SYNTHES AG CHUR (3)
8,764,831 Intervertebral implant 0 2010
8,715,354 Intervertebral implant 0 2011
8,709,085 Intervertebral implant 0 2011
 
DEPUY SYNTHES PRODUCTS, LLC (2)
8,540,774 Low profile intervertebral implant 0 2008
* 8,840,677 Allograft bone plugs, systems and techniques 0 2010
 
DOCTORS RESEARCH GROUP, INC. (2)
7,964,207 Methods of performing medical procedures that promote bone growth, method of making compositions that promote bone growth, and apparatus for use in such methods 1 2005
8,211,458 Methods of performing medical procedures that promote bone growth, methods of making compositions that promote bone growth, and apparatus for use in such methods 1 2011
 
CHILDREN'S MEDICAL CENTER CORPORATION (1)
* 6,165,487 Methods and compositions for programming an organic matrix for remodeling into a target tissue 23 1998
 
DANEK MEDICAL, INC. (1)
* 7,981,156 Bone grafts 1 2004
 
EBI, LLC (1)
7,621,963 Composite bone graft material 19 2006
 
ETEX CORPORATION (1)
7,582,309 Cohesive demineralized bone compositions 1 2002
 
GENDLER FAMILY LIMITED PARTNERSHIP (1)
6,576,249 Bone putty and method 24 2000
 
LIFENET HEALTH (1)
7,494,811 In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby 1 2004
 
MARFLY 2, LP (1)
8,563,040 Compositions and methods for forming and strengthening bone 0 2009
 
NORIAN CORPORATION (1)
6,334,891 Paste compositions capable of setting into carbonated apatite 23 1999
 
OSPREY BIOMEDICAL, INC. (1)
8,043,377 Implantable intervertebral fusion device 2 2006
 
OSTEOTECH, INC. (1)
6,752,831 Biocompatible osteogenic band for repair of spinal disorders 177 2000
 
SMITH & NEPHEW, INC. (1)
8,308,340 Composite mixer 0 2005
 
SPINEOLOGY, INC. (1)
7,959,683 Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation 11 2007
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
8,652,503 Bone paste 0 2005
 
WBK, INC. (1)
* 5,788,976 Method for effecting bone repair 43 1996
 
ZIMMER SPINE, INC. (1)
D580551 Spinal implant 5 2007
 
Other [Check patent profile for assignment information] (2)
6,372,257 Compositions and methods for forming and strengthening bone 41 2000
8,911,759 Bone matrix compositions and methods 0 2006
* Cited By Examiner