Method of amphiphatic drug loading in liposomes by ammonium ion gradient

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United States of America Patent

PATENT NO 5316771
SERIAL NO

07992997

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Abstract

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An improved simple, efficient, safe, economical, and fast transmembrane ling procedure for efficient active loading of weak amphiphatic drugs into liposomes using the transmembrane gradient. The resulting liposomes loaded with the amphiphatic drug are stable and safe. A storagable form of loadable liposomes has extended period of stability. The reversed procedure is applicable for sustained release of liposome encapsulated drugs from ammonium liposomes.

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Patent Owner(s)

  • YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barenholz, Yechezkel Jerusalem, IL 92 1337
Haran, Gilad Jerusalem, IL 2 462

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