Homogeneous denatured human 06-guanine alkyltransferase prepared by immunoaffinity chromatography using monoclonal antibody specific for enzyme
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United States of America Patent
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May 31, 1994
Issued Date -
N/A
app pub date -
May 11, 1993
filing date -
Mar 24, 1989
priority date (Note) -
Expired
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Abstract
A denatured human O.sup.6 -guanine alkyltransferase is disclosed. The enzyme is prepared by a process which involves denaturing the enzyme, contacting the denatured enzyme with a monoclonal antibody specific for the denatured enzyme on a substrate to which the monoclonal antibody is bound to, so that the denatured enzyme and the monoclonal antibody form an immunocomplex and then, eluting the denatured enzyme from the substrate-bound monoclonal antibody so that the denatured human O.sup.6 -guanine alkyltransferase is obtained. The enzyme can be used to develop probes for the Mer.sup.- phenotype and these probes in turn are contemplated for use in identifying drug resistant tumors in patients.
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