Production of recombinant bone-inducing proteins
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United States of America Patent
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Jun 7, 1994
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app pub date -
Apr 2, 1991
filing date -
Apr 2, 1991
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Abstract
An improved process for producing recombinant bone-inducing protein of the BMP-2 family as described. A suitable mammalian host cell transformed with a DNA encoding the protein is cultured in an appropriate culture medium to which is added about 10 to 1000 .mu.g/ml dextran sulfate. The presence of dextran sulfate in the medium results in an increased yield of recombinant bone-inducing protein.
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