US Patent No: 5,321,501

Number of patents in Portfolio can not be more than 2000

Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample

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Abstract

A method and apparatus for performing optical imaging on a sample wherein longitudinal scanning or positioning in the sample is provided by either varying relative optical path lengths for an optical path leading to the sample and to a reference reflector, or by varying an optical characteristic of the output from an optical source applied to the apparatus. Transverse scanning in one or two dimensions is provided on the sample by providing controlled relative movement between the sample and a probe module in such direction and/or by steering optical radiation in the probe module to a selected transverse position. The probe module may be an external module or may be an endoscope or angioscope utilized for scanning internal channels. Multiple optical paths may be provided for parallel scanning and focus may be enhanced by varying the focal point in the sample in synchronism with longitudinal scanning of the sample.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA3998

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujimoto, James G Cambridge, MA 17 2247
Huang, David Cleveland Heights, OH 85 1303
Lin, Charles P Arlington, MA 38 929
Puliafito, Carmen A Pinecrest, FL 13 876
Schuman, Joel S Wayland, MA 8 470
Swanson, Eric A Acton, MA 23 2734

Cited Art

Patent Info (Count) # Cites Year
 
AGILENT TECHNOLOGIES, INC. (1)
5,202,745 Polarization independent optical coherence-domain reflectometry 147 1992
 
THOMSON-CSF (1)
4,928,005 Multiple-point temperature sensor using optic fibers 86 1989

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
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LUMEND, INC. (23)
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CARL ZEISS MEDITEC, INC. (21)
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LUMA IMAGING CORPORATION (19)
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LIGHTLAB IMAGING, INC. (14)
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VISIONGATE, INC. (13)
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CARL ZEISS MEDITEC AG (9)
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GLT ACQUISITION CORP. (7)
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OLYMPUS CORPORATION (7)
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CARL ZEISS, INC. (6)
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ENDOSENSE SA (6)
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IMALUX CORPORATION (6)
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LUCENT TECHNOLOGIES INC. (6)
6,587,206 Method for characterizing particles in a liquid medium using interferometry 2 2000
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ROBERT BOSCH GMBH (6)
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6,813,029 Interferometric measuring device for form measurement 5 2002
 
CARL ZEISS JENA GMBH (5)
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COVIDIEN LP (5)
8,246,640 Methods and devices for cutting tissue at a vascular location 0 2006
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FOX HOLLOW TECHNOLOGIES, INC. (5)
7,771,444 Methods and devices for removing material from a body lumen 5 2001
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY (5)
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ALCON LENSX, INC. (4)
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CARESTREAM HEALTH, INC. (4)
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OLYMPUS OPTICAL CO., LTD. (4)
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OTI OPHTHALMIC TECHNOLOGIES INC. (4)
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PENTAX CORPORATION (4)
6,527,708 Endoscope system 25 2000
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SCIMED LIFE SYSTEMS, INC. (4)
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TERUMO KABUSHIKI KAISHA (4)
8,157,741 Rotational imaging probe safety mechanism for conditional rotational speed reduction 0 2007
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THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (4)
5,920,390 Fiberoptic interferometer and associated method for analyzing tissue 84 1997
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UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (4)
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UNIVERSITY OF MIAMI (4)
7,301,644 Enhanced optical coherence tomography for anatomical mapping 32 2005
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UNIVERSITY OF WASHINGTON (4)
7,616,986 Optical fiber scanner for performing multimodal optical imaging 8 2004
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8,396,535 Integrated optical scanning image acquisition and display 0 2009
 
AGFA HEALTHCARE N.V. (3)
8,339,610 System and method for optical coherence tomography with spectrally modulated light injected into optical fibre 0 2008
8,330,962 System and method for optical coherence tomography with modulated detector sensitivity 0 2008
8,199,327 System for optical coherence tomography 2 2008
 
BIOPTIGEN, INC. (3)
7,830,525 Optical coherence imaging systems having a mechanism for shifting focus and scanning modality and related adapters 5 2007
7,999,947 Optical coherence imaging systems having a mechanism for shifting focus and scanning modality and related adapters 0 2010
8,120,779 Optical coherence imaging systems having a mechanism for shifting focus and scanning modality 0 2010
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (3)
7,747,315 Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures 0 2003
7,177,491 Fiber-based optical low coherence tomography 6 2003
7,983,736 Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures 0 2010
 
FUJIFILM CORPORATION (3)
7,864,331 Optical coherence tomographic imaging apparatus 0 2007
7,830,524 Optical tomograph using a plurality of wavelength-swept light beams 0 2007
8,174,701 Optical tomographic imaging system 0 2008
 
OPTIMEDICA CORPORATION (3)
8,394,084 Apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation 0 2006
8,425,497 Method and apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation 0 2011
8,403,921 Method and apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation 0 2012
 
TYCO HEALTHCARE GROUP LP (3)
7,699,790 Debulking catheters and methods 10 2004
7,794,413 Libraries and data structures of materials removed by debulking catheters 0 2005
7,989,207 Testing lumenectomy samples for markers of non-vascular diseases 0 2006
 
VOLCANO CORPORATION (3)
8,047,996 System and method for reducing angular geometric distortion in an imaging device 0 2005
7,785,286 Method and system for imaging, diagnosing, and/or treating an area of interest in a patient's body 1 2006
8,414,496 System and method for reducing angular geometric distortion in an imaging device 0 2011
 
ZETETIC INSTITUTE (3)
5,760,901 Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation 70 1997
6,091,496 Multiple layer, multiple track optical disk access by confocal interference microscopy using wavenumber domain reflectometry and background amplitude reduction and compensation 100 1998
6,480,285 Multiple layer confocal interference microscopy using wavenumber domain reflectometry and background amplitude reduction and compensation 45 2000
 
AMO MANUFACTURING USA, LLC (2)
7,133,137 Integrated scanning and ocular tomography system and method 11 2003
7,503,916 Integrated scanning and ocular tomography system and method 4 2006
 
ANGIODYNAMICS, INC. (2)
7,025,765 Tissue biopsy and treatment apparatus and method 49 2001
6,869,430 Tissue biopsy and treatment apparatus and method 22 2001
 
ASAHI KOGAKU KOGYO KABUSHIKI KAISHA (2)
6,477,403 Endoscope system 68 2000
6,456,769 Fiber bundle and endoscope apparatus 35 2000
 
AVINGER, INC. (2)
8,062,316 Catheter system and method for boring through blocked vascular passages 1 2008
8,361,097 Catheter system and method for boring through blocked vascular passages 0 2011
 
BIOTEX, INC. (2)
7,236,812 System, device and method for determining the concentration of an analyte 57 2004
8,364,217 System, device and method for determining the concentration of an analyte 0 2007
 
BOSTON SCIENTIFIC CORPORATION (2)
5,957,941 Catheter system and drive assembly thereof 89 1996
5,827,313 Device for controlled longitudinal movement of an operative element within a catheter sheath and method 77 1996
 
CANON KABUSHIKI KAISHA (2)
8,204,300 Image forming method and optical coherence tomograph apparatus using optical coherence tomography 1 2008
8,384,908 Image forming method and optical coherence tomograph apparatus using optical coherence tomography 0 2012
 
CARDIOLUMEN, INC. (2)
7,242,480 Low coherence interferometry for detecting and characterizing plaques 59 2005
7,488,930 Multi-channel low coherence interferometer 5 2006
 
CARL ZEISS SURGICAL GMBH (2)
7,488,070 Optical measuring system and optical measuring method 5 2006
7,901,080 Ophthalmologic surgical microscope system having an OCT-measuring device 4 2009
 
CARL-ZEISS-STIFTUNG (2)
7,016,046 Interferometer arrangement and interferometric measuring method 3 2002
7,209,238 Interferometer arrangement and interferometric measuring method 0 2005
 
FUJINON CORPORATION (2)
7,428,052 Optical tomographic apparatus 10 2005
7,705,992 Optical coherence tomography system 1 2007
 
HEIDELBERG ENGINEERING GMBH (2)
6,095,648 Process and arrangement for examining a section of the eye 20 1999
6,748,128 Device for changing the length of the running path of an electromagnetic wave 1 2001
 
HITACHI MEDICAL CORPORATION (2)
7,039,454 Biological optical measuring instrument 10 2000
7,778,694 Biological optical measurement instrument 0 2006
 
LASER DIAGNOSTIC TECHNOLOGIES, INC. (2)
6,137,585 Method and apparatus for recording three-dimensional distribution of light backscattering potential in transparent and semi-transparent structures 22 1998
7,145,661 Efficient optical coherence tomography (OCT) system and method for rapid imaging in three dimensions 19 2003
 
MEDISPECTRA, INC. (2)
7,103,401 Colonic polyp discrimination by tissue fluorescence and fiberoptic probe 3 2002
7,187,810 Methods and systems for correcting image misalignment 24 2002
 
OPTOVUE, INC. (2)
7,280,221 High efficiency low coherence interferometry 6 2005
7,140,730 Optical apparatus and method for comprehensive eye diagnosis 2 2005
 
SOUTHWEST SCIENCES INCORPORATED (2)
7,079,254 Method and apparatus for imaging internal structures of transparent and translucent materials 9 2004
7,394,546 Method and apparatus for full phase interferometry 3 2006
 
TAYLOR HOBSON LIMITED (2)
7,518,733 Surface profiling apparatus 1 2003
7,948,634 Surface profiling apparatus 0 2008
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
6,208,415 Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography 96 1998
7,576,865 Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle 0 2006
 
THE SPECTRANETICS CORPORATION (2)
6,852,109 Radio frequency guide wire assembly with optical coherence reflectometry guidance 14 2002
7,563,262 Radio frequency guide wire assembly with optical coherence reflectometry guidance 0 2004
 
THORLABS, INC. (2)
7,843,976 Compact multimode laser with rapid wavelength scanning 1 2006
8,351,474 Compact multimode laser with rapid wavelength scanning 0 2010
 
UNIVERSITY HEALTH NETWORK (2)
7,242,833 Method and apparatus for high resolution coherent optical imaging 6 2001
7,972,272 Electrostatically driven image probe 0 2008
 
UNIVERSITY HOSPITALS OF CLEVELAND (2)
6,615,072 Optical imaging device 30 1999
6,564,089 Optical imaging device 83 2002
 
VZN CAPITAL, LLC (2)
7,184,148 Low coherence interferometry utilizing phase 15 2004
7,190,464 Low coherence interferometry for detecting and characterizing plaques 60 2005
 
AVAGO TECHNOLOGIES GENERAL IP PTE. LTD. (1)
5,864,400 Method of and device for measuring return losses in optical fiber components 2 1998
 
BOSTON BEER CORPORATION (1)
8,097,864 System, method and computer-accessible medium for providing wide-field superresolution microscopy 0 2010
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (1)
6,882,429 Transverse optical fiber devices for optical sensing 16 2000
 
CARL ZEISS AG (1)
7,358,516 System and method for determining a position or/and orientation of two objects relative to each other as well as beam guiding arrangement, interferometer arrangement and device for changing an optical path length for use in such a system and method 2 2002
 
CARL ZEISS SMT GMBH (1)
8,243,281 Method and system for measuring a surface of an object 0 2008
 
CHEMOMETEC A/S (1)
8,154,731 Method and a system for the assessment of samples 0 2005
 
CYBERNET SYSTEMS CORPORATION (1)
6,043,870 Compact fiber optic electronic laser speckle pattern interferometer 12 1997
 
DANMARKS TEKNISKE UNIVERSITET (1)
6,853,457 Optical amplification in coherence reflectometry 8 2003
 
DEGUDENT GMBH (1)
7,872,760 Method and device for detecting the contour data and/or optical characteristics of a three-dimensional semi-transparent object 1 2005
 
EP TECHNOLOGIES, INC. (1)
6,522,913 Systems and methods for visualizing tissue during diagnostic or therapeutic procedures 21 1999
 
FOXHOLLOW TECHNOLOGIES, INC. (1)
7,927,784 Vascular lumen debulking catheters and methods 0 2006
 
GN NETTEST (OREGON), INC. (1)
6,122,043 Method and apparatus for electrically reducing coherence/polarization noise in reflectometers 18 1997
 
HARVEY MUDD COLLEGE (1)
6,608,717 Optical coherence microscope and methods of use for rapid in vivo three-dimensional visualization of biological function 32 2000
 
KABUSHIKI KAISHA TOPCON (1)
7,641,338 Fundus observation device 3 2007
 
KENSEY NASH CORPORATION (1)
7,674,253 Catheter for conducting a procedure within a lumen, duct or organ of a living being 2 2006
 
KOWA COMPANY, LTD. (1)
6,198,540 Optical coherence tomography have plural reference beams of differing modulations 29 1999
 
LEICA AG (1)
5,519,491 Process for measuring the inclination of boundary areas in an optical system using interferometry to extract reflections from disturbance-generating boundary areas 4 1994
 
LEICA MICROSYSTEMS CMS GMBH (1)
7,075,716 Arrangement for spectrally sensitive reflected-light and transmitted-light microscopy 0 2002
 
LIGHLAB IMAGING, INC. (1)
6,570,659 Broadband light source system and method and light source combiner 27 2001
 
LIGHTLAB IMAGING, LLC (1)
7,625,366 Flush catheter with flow directing sheath 3 2007
 
LINVATEC CORPORATION (1)
5,841,491 Fiberscope enhancement system 3 1996
 
LUNA INNOVATIONS INCORPORATED (1)
7,379,168 Polarization diversity detection without a polarizing beam splitter 1 2003
 
MASSACHUSETTS EYE & EAR INFIRMARY (1)
8,045,177 Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy 0 2008
 
MEDRIKON CORPORATION (1)
7,327,463 Low coherence interferometry utilizing magnitude 5 2004
 
MTEX MATSUMURA CORPORATION (1)
7,227,646 High-speed optical delay generating method by rotation reflector in optical coherence tomography and optical coherence tomography device 0 2002
 
NAMIKI SEIMITSU HOUSEKI KABUSHIKI KAISHA (1)
7,805,034 OCT probe for eliminating ghost images 26 2009
 
NATIONAL RESEARCH COUNCIL OF CANADA (1)
6,873,419 Method and apparatus for three-dimensional compositional mapping of heterogeneous materials 5 2001
 
NIPPON TELEGRAPH AND TELEPHONE CORPORATION (1)
6,760,110 Low coherent reflectometer 2 2001
 
NORTHROP GRUMMAN SYSTEMS CORPORATION (1)
5,422,721 Fourier transform spectroscopy by varying the path length difference between the paths in each of a plurality of pairs of optical paths 6 1994
 
NOVELIS INVESTMENTS, CANADA (1)
7,612,773 Apparatus and method for rendering for display forward-looking image data 2 2006
 
OTI OPHTHALMIC TECHLOGIES INC. (1)
7,872,761 Method for reliable optical coherence tomography scans of volumes of retinal tissue 2 2008
 
PERCEPTRONIX MEDICAL INC. (1)
6,546,272 Apparatus for in vivo imaging of the respiratory tract and other internal organs 22 2000
 
PHYSICAL OPTICS CORPORATION (1)
6,014,215 Self-referencing interferometric fiber optic sensor system having a transducer mechanism with a position reference reflector 8 1998
 
PRESCIENT MEDICAL, INC. (1)
7,952,719 Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry 0 2008
 
SAMSUNG ELECTRONICS CO., LTD. (1)
8,411,366 Optical probe and optical system therefor 0 2011
 
SPARTA, INC. (1)
5,543,914 Apparatus and methods employing harmonic analysis for measuring the difference in phase between two coherent beams 11 1995
 
SPECTRASCIENCE, INC. (1)
6,174,291 Optical biopsy system and methods for tissue diagnosis 124 1998
 
SYNERON MEDICAL LTD. (1)
7,333,698 Optical scanning device 12 2004
 
TEXAS CHRISTIAN UNIVERSITY (1)
6,597,458 Method and system for stabilizing and demodulating an interferometer at quadrature 11 2001
 
THE CLEVELAND CLINIC FOUNDATION (1)
7,347,548 Method and apparatus for measuring a retinal sublayer characteristic 6 2004
 
TRANSPACIFIC SYSTEMS, LLC (1)
8,194,290 Image compensation method with correctional gray level values of complete black and/or white 0 2003
 
UCHICAGO ARGONNE, LLC (1)
6,559,950 Method for monitoring a characteristic of a mixture comprising particles suspended in a liquid 1 2000
 
UNIVERSITY OF KENT (1)
7,466,423 Optical mapping apparatus 7 2005
 
VAN DE VELDE; JOZEF F. (1)
7,703,922 Relaxed confocal catadioptric scanning laser ophthalmoscope 1 2008
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (9)
6,014,214 High speed inspection of a sample using coherence processing of scattered superbroad radiation 70 1997
5,905,572 Sample inspection using interference and/or correlation of scattered superbroad radiation 12 1997
5,892,583 High speed inspection of a sample using superbroad radiation coherent interferometer 84 1997
8,046,057 Tissue structure identification in advance of instrument 0 2002
7,170,610 Low-coherence inferometric device for light-optical scanning of an object 8 2003
7,023,563 Interferometric optical imaging and storage devices 10 2003
7,280,222 Compact optical apparatus 0 2005
7,310,151 Interferometric optical apparatus and method using wavefront division 0 2005
7,385,175 Bi-directional optical transmission system and method 1 2005