Alteration of pharmacokinetics of proteins by charge modification
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United States of America Patent
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Jun 21, 1994
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N/A
app pub date -
Feb 17, 1988
filing date -
Feb 17, 1988
priority date (Note) -
Expired
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Abstract
There is disclosed charge-modified conjugates comprising a targeting protein bound to a therapeutic or diagnostic agent. Charge-modifying a conjugate to cause an acidic shift in the isoelectric point results in prolonged serum half-life upon in vivo administration and is useful to accumulate a therapeutic agent at the target site. Conversely, charge-modification to cause a basic shift in the isoelectric point of the conjugate reduces serum half-life upon in vivo use for diagnostic imaging purposes and results in higher target-to-background ratios.
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