Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents
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United States of America Patent
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Aug 9, 1994
Grant Date -
N/A
app pub date -
Dec 11, 1992
filing date -
Dec 11, 1992
priority date (Note) -
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Abstract
A treatment for metallic surfaces and devices having metallic surfaces is described. A film of heptafluorobutylmethacrylate (HFBMA) is applied to a surface by radiofrequency (RF) plasma deposition and subsequently treated with a biologically active agent. A water vapor RF plasma treatment of the HFBMA coating provides reactive groups thereon which can covalently bond to the biologically active agent. Alternatively, a spacer group can be bonded to the activated HFBMA and the biologically active agent can then be bonded to the spacer group. Devices coated according to the invention possess enhanced biocompatibility and the HFBMA coatings are durable even under severe crimping and expansion conditions.
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