CD4 adheson variants
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United States of America Patent
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Aug 9, 1994
Issued Date -
N/A
app pub date -
Aug 26, 1992
filing date -
Oct 2, 1987
priority date (Note) -
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Abstract
Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics.
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