Method for preparation of taxol
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United States of America Patent
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-
Aug 9, 1994
Issued Date -
N/A
app pub date -
Oct 26, 1992
filing date -
May 31, 1989
priority date (Note) -
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status (Latency Note)
Importance
Abstract
A .beta.-lactam of the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, alkyl, acyl, acetal, ethoxyethyl, or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; and process for the preparation of taxol comprising contacting said .beta.-lactam and an alcohol in the presence of an activating agent to provide a taxol intermediate, and converting the intermediate to taxol.
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