Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport
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United States of America Patent
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Aug 30, 1994
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app pub date -
Jun 8, 1993
filing date -
Jun 8, 1993
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Abstract
Analogs of cytochalasin B are used as radiopharmaceuticals to provide an image for the nuclear imaging of glucose transport across cell membranes. Like cytochalasin B, the analogs bind specifically to glucose transport protein, and in doing so, serve as markers indicating the amount of glucose transport protein present on the surfaces of cells. The analogs differ from cytochalasin B by the inclusion of a radionuclide in the region of the terminal phenyl group on cytochalasin B, where the radionuclide does not interfere with the binding specificity of the analog. Disclosed herein are such analogs as well as analogs with which readily accept radionuclides at the desired location on the structure, either by conjugation or substitution.
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