Phenothiazine derivatives, their production and use
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United States of America Patent
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-
Sep 6, 1994
Grant Date -
N/A
app pub date -
Apr 14, 1992
filing date -
Apr 26, 1991
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
There is disclosed a novel phenothiazine derivative of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are a C.sub.1-6 alkyl group and at least one of them has as a substituent a group which can react with amino group, thiol group or carboxyl group, and X.sup.- is a counter ion of the phenazathionium. Their production and the intermediates used in the production are also disclosed. The compound (I) is a derivative of methylene blue and is applicable to photodynamic therapy of cancer or immunoassays utilizing chemiluminescence.
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