Isolated, large latent complexes of TGF-.beta.2 and TGF-.beta.3, and new binding protein for latent form TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3 LTBP-2
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United States of America Patent
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Sep 13, 1994
Issued Date -
N/A
app pub date -
Jul 15, 1993
filing date -
Jan 27, 1992
priority date (Note) -
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status (Latency Note)
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Abstract
The invention relates to large latent complexes of TGF-.beta.2 and TGF-.beta.3, and methods for isolating these. The complex consists of a dimerized form of TGF-.beta.2 or TGF-.beta.3, the appropriate latency associated peptide, and the latent TGF-.beta.1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3, but is immunologically distinct from LTBP, referred to as LTBP-2.
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