Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan
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United States of America Patent
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Sep 27, 1994
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app pub date -
May 28, 1992
filing date -
Jun 17, 1991
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Abstract
This invention discloses a method for increasing the effectiveness of dextromethorphan (DM) as an antitussive agent (i.e., as a cough suppressant). This method involves the concurrent administration of DM and a second agent which inhibits the oxidative activity of debrisoquin hydroxylase, a cytochrome P450 oxidase enzyme. Effective anti-oxidant compounds include quinidine, yohimbine, and fluoxetine.
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