Method for improving the biocompatibility of solid surfaces
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United States of America Patent
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Sep 27, 1994
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N/A
app pub date -
Jan 19, 1993
filing date -
Jan 19, 1993
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Abstract
A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is 'selective' since the bonds between the biomolecule and the aminated solid surface remain intact.
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