Process for the preparation of substituted tetrahydrofolico derivatives in the [6(R,S)(-)] forms and of their active [6(S)(-)] N.sup.5 diastereoisomers in form of alkali and alkaline earth metal salts
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United States of America Patent
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Sep 27, 1994
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N/A
app pub date -
Oct 7, 1992
filing date -
Oct 10, 1991
priority date (Note) -
Expired
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Abstract
Process for the preparation of the optically active [6(S)(-)]N.sup.5 alkaline earth metal salts of methyltetrahydrofolic acid and formyltetrahydrofolic acid wherein an aqueous solution of folic acid is hydrogenated with a high stoichiometric excess of sodium borohydride followed by treating the reaction product with formic aldehyde and optionally further with sodium borohydride when the methyl derivative is desired. Reaction with a salt of the alkaline earth metal precipitates the desired optically active alkaline earth metal salt.
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