Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same
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United States of America Patent
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Oct 4, 1994
Issued Date -
N/A
app pub date -
Nov 22, 1993
filing date -
Nov 2, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention is a mixture including a solvent, a first surfactant and a second, dispersible surfactant different from the first surfactant, the mixture having stabilized gas microbubbles formed therein by sonication. The gas microbubbles are useful in ultrasonic diagnostics. Preferably the first surfactant is substantially soluble in the solvent and the second surfactant is substantially insoluble in the solvent. The present invention also includes a process for preparing the stabilized gas microbubbles and a method for altering the contrast of an ultrasonic image using the microbubbles as a contrast agent.
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