Oral administration of antigens
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United States of America Patent
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Oct 4, 1994
Grant Date -
N/A
app pub date -
Jul 20, 1992
filing date -
Jul 20, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An oral vaccine formulation is provided for stimulation of an immune response in gut-associated lymphoid tissues. The formulation comprises an enzymatically degradable antigen in a hydrogel matrix. In ruminant species, the vaccine formulation, upon oral administration, is formed to pass through the rumen without substantial hydration and then into the post-ruminal portion of the digestive tract where the antigen is released for contact with the gut-associated lymphoid tissue.
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