Importance

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Abstract

The invention pertains to a method of preparing a device for transdermal delivery of an active ingredient which is solid at room temperature and in which part or all of the active ingredient is present in a saturated or supersaturated solution. In the first step, a mixture is prepared which includes at least a polymer adhesive, a vehicle for the polymer adhesive, an active ingredient and a solvent mixture for the active ingredient which solvent mixture comprises at least two solvents having different boiling points. The mixture is then formed into a film and dried. The vehicle for the polymer adhesive and at least one of the solvents and the solvent mixture have boiling points below the drying temperature of the film, while at least one of the solvents in the solvent mixture has a boiling point above the drying temperature of the film. Thus, at least one of the solvents remains in the film after drying and the solubility of the active ingredient contained in the remaining solvent is greater than 10%.

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First Claim