Supported drugs with increased dissolution rate, and a process for their preparation
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United States of America Patent
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Oct 11, 1994
Issued Date -
N/A
app pub date -
Jan 30, 1992
filing date -
Nov 28, 1988
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Supported drugs with an increased dissolution rate, prepared by a process comprising mixing the drug with the support material under dry conditions, co-grinding the mixture in a mill with its grinding chamber saturated with the vapour of one or more solvents able to solubilize the drug or to be adsorbed on the surface of the support material, vacuum-drying the product obtained, and sieving. The drugs obtained in this manner have a reduced heat of fusion, a reduced melting point, an increased dissolution rate and an increased solubilization kinetics.
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