Biocompatible metal surfaces
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United States of America Patent
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Oct 18, 1994
Issued Date -
N/A
app pub date -
Nov 3, 1993
filing date -
Aug 13, 1991
priority date (Note) -
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Abstract
Metallic surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The surfaces are prepared by a two-step procedure including covalently linking an organosilane having amine reactive sites with the surface of the metallic member, typically through a metal oxide thereof. Thereafter, a biologically active agent is covalently linked to the organosilane coating. The two-step process is particularly advantageous for preparing medical devices in the form of stents which need to be bent and flexed during implantation procedures.
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