Carbohydrate glass matrix for the sustained release of a therapeutic agent
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United States of America Patent
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Oct 18, 1994
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app pub date -
Jul 13, 1993
filing date -
Dec 5, 1991
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Abstract
A composition for the sustained release of a biologically active therapeutic agent wherein the matrix of the sustained release composition is composed of an amorphous carbohydrate glass matrix comprising a suitable carbohydrate and an agent which retards the recrystallization of the carbohydrate and a biologically active therapeutic agent and a water-insoluble wax dispersed throughout the matrix. Biologically active therapeutic agents which can be incorporated into the carbohydrate glass matrix include prolactin, growth hormones, serum albumins, growth factors or any biologically active fragment or recombinant form thereof.
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