Implantable microdevice with self-attaching electrodes

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United States of America Patent

PATENT NO 5358514
SERIAL NO

08062283

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An implantable microminiature stimulator and/or sensor (microdevice) is housed within a sealed housing that includes all the requisite electronic circuitry for inductively receiving power and control signals to sense of biopotential or other biomedical signals and/or to generate electrical stimulation pulse(s) between opposing electrodes. In a preferred embodiment, the housing of the microdevice is tubular, with opposing electrodes extending from each end. The electrodes are self-attaching electrodes that attach to a nerve or muscle without suturing. The electrodes are configured to helically curl around the desired nerve, thereby permitting the microdevice to stimulate the nerve or muscle, or sense signals associated with the nerve or muscle, using a minimal amount of energy. The electrodes and microdevice are sufficiently small to allow attachment to a single nerve, thereby preventing tethering of the nerve or muscle, and to allow their implantation within living tissue through small incisions or puncture holes. The muscle or nerve to which the microdevice is attached may be of any type, e.g., skeletal, smooth or cardiac.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCHSANTA CLARITA, CA171

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Meadows, Paul Altadena, CA 6 1567
Schulman, Joseph H Santa Clarita, CA 160 23349
Strojnik, Primoz Granada Hills, CA 14 3979

Cited Art Landscape

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8231532 Analyte monitoring device and methods of use 4 2007
7920907 Analyte monitoring system and method 30 2007
9498159 Analyte monitoring device and methods of use 0 2007
9011332 Analyte monitoring device and methods of use 0 2007
8732188 Method and system for providing contextual based medication dosage determination 0 2008
8461985 Analyte monitoring system and methods 31 2008
8456301 Analyte monitoring system and methods 1 2008
7928850 Analyte monitoring system and methods 60 2008
8103456 Method and device for early signal attenuation detection using blood glucose measurements 7 2009
8255031 Analyte monitoring device and methods of use 0 2009
8226555 Analyte monitoring device and methods of use 3 2009
8162829 Analyte monitoring device and methods of use 0 2009
8162830 Analyte monitoring device and methods of use 0 2009
8647269 Glucose measuring device for use in personal area network 6 2009
8512239 Glucose measuring device for use in personal area network 0 2009
8688188 Analyte monitoring device and methods of use 6 2009
8665091 Method and device for determining elapsed sensor life 0 2009
8465425 Analyte monitoring device and methods of use 5 2009
8346337 Analyte monitoring device and methods of use 27 2009
8149117 Analyte monitoring system and methods 1 2009
8593109 Method and system for powering an electronic device 0 2009
8175673 Analyte monitoring device and methods of use 1 2009
8235896 Analyte monitoring device and methods of use 0 2009
8177716 Analyte monitoring device and methods of use 2 2009
8268243 Blood glucose tracking apparatus and methods 0 2009
8226557 Analyte monitoring device and methods of use 0 2009
8930203 Multi-function analyte test device and methods therefor 1 2010
8236242 Blood glucose tracking apparatus and methods 11 2010
9226701 Error detection in critical repeating data in a wireless sensor system 0 2010
8585591 Method and system for providing basal profile modification in analyte monitoring and management systems 0 2010
9314195 Analyte signal processing device and methods 0 2010
8993331 Analyte monitoring system and methods for managing power and noise 0 2010
8287454 Analyte monitoring device and methods of use 6 2010
9320461 Method and apparatus for providing notification function in analyte monitoring systems 0 2010
8187183 Continuous glucose monitoring system and methods of use 8 2010
8765059 Blood glucose tracking apparatus 0 2010
8362904 Analyte monitoring system and methods 0 2011
9066697 Analyte monitoring device and methods of use 0 2011
8473220 Method and device for early signal attenuation detection using blood glucose measurements 3 2012
9095290 Method and apparatus for providing rolling data in communication systems 0 2012
8622903 Continuous glucose monitoring system and methods of use 5 2012
8652043 Analyte monitoring device and methods of use 0 2012
8593287 Analyte monitoring system and methods 0 2012
8597575 Analyte monitoring devices and methods therefor 1 2012
8920319 Analyte monitoring device and methods of use 0 2012
9035767 Analyte monitoring system and methods 0 2013
9177456 Analyte monitoring system and methods 0 2013
9078607 Analyte monitoring device and methods of use 1 2013
9020573 Analyte monitoring device and methods of use 0 2013
8676513 Method and device for early signal attenuation detection using blood glucose measurements 0 2013
9323898 Method and system for providing basal profile modification in analyte monitoring and management systems 0 2013
9000929 Analyte monitoring system and methods 1 2013
8933664 Method and system for powering an electronic device 0 2013
9039975 Analyte monitoring devices and methods therefor 0 2013
9574914 Method and device for determining elapsed sensor life 0 2014
9066709 Method and device for early signal attenuation detection using blood glucose measurements 0 2014
8915850 Analyte monitoring device and methods of use 1 2014
9380971 Method and system for powering an electronic device 0 2014
9326716 Analyte monitoring device and methods of use 0 2014
9314198 Analyte monitoring system and methods 1 2015
9610034 Analyte monitoring device and methods of use 0 2015
 
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6974437 Microprocessor controlled ambulatory medical apparatus with hand held communication device 391 2001
6733446 Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periods 500 2001
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6950708 Ambulatory medical apparatus and method using a telemetry system with predefined reception listening 462 2002
7678071 Microprocessor controlled ambulatory medical apparatus with hand held communication device 24 2003
7831310 Microprocessor controlled ambulatory medical apparatus with hand held communication device 74 2004
8568356 Ambulatory medical apparatus with hand held communication device 0 2011
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7580753 Method and system for stimulating a dorsal root ganglion 92 2005
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7450993 Methods for selective stimulation of a ganglion 32 2005
7447546 Methods of neurostimulating targeted neural tissue 41 2005
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9427570 Expandable stimulation leads and methods of use 0 2007
9314618 Implantable flexible circuit leads and methods of use 0 2007
8983624 Delivery devices, systems and methods for stimulating nerve tissue on multiple spinal levels 4 2007
9044592 Sutureless lead retention features 3 2008
8712546 Neurostimulation system 7 2008
8229565 Methods for stimulating a dorsal root ganglion 16 2009
9056197 Selective stimulation systems and signal parameters for medical conditions 2 2009
8380318 Pain management with stimulation subthreshold to paresthesia 19 2010
9259569 Methods, systems and devices for neuromodulating spinal anatomy 0 2010
8518092 Hard tissue anchors and delivery devices 4 2011
9327110 Devices, systems and methods for the targeted treatment of movement disorders 0 2012
9205259 Neurostimulation system 1 2012
9205260 Methods for stimulating a dorsal root ganglion 1 2012
9205261 Neurostimulation methods and systems 1 2012
9468762 Pain management with stimulation subthreshold to paresthesia 0 2015
9409021 Selective stimulation systems and signal parameters for medical conditions 0 2015
 
MICRON DEVICES LLC (6)
9409030 Neural stimulator system 0 2012
9199089 Remote control of power or polarity selection for a neural stimulator 2 2012
8849412 Microwave field stimulator 5 2012
9242103 Relay module for implant 2 2012
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9409029 Remote RF power system with low profile transmitting antenna 0 2015
 
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SIMON FRASER UNIVERSITY (1)
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9144683 Post-shock treatment in a subcutaneous device 0 2006
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8706217 Cardioverter-defibrillator having a focused shocking area and orientation thereof 2 2012
8718760 Subcutaneous implantable cardioverter-defibrillator placement methods 5 2013
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7931597 Anchored implantable pressure monitor 3 2010
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7013178 Implantable medical device communication system 62 2002
7742818 Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof 23 2003
7620454 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof 48 2003
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7139613 Implantable medical device communication system with pulsed power biasing 20 2003
7286884 Implantable lead including sensor 9 2004
8265770 Driver circuitry switchable between energy transfer and telemetry for an implantable medical device 9 2004
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8382677 Anchored implantable pressure monitor 0 2011
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Micro Devices, LLC (1)
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UNIVERSITY OF ROCHESTER (4)
8938300 Leadless implantable intravascular electrophysiologic device for neurologic/cardiovascular sensing and stimulation 2 2005
8849416 Implantable bio-electro-physiologic interface matrix 0 2005
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7047085 Nerve stimulator output control needle with depth determination capability and method of use 1 2004
7212865 Nerve stimulator and method 66 2004
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8027735 Atraumatic high-retention headpiece 5 2009
 
CKM DIAGNOSTICS, INC. (1)
* 2004/0158,304 Nerve stimulator output control needle with depth determination capability and method of use 12 2004
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
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WOLFE RESEARCH PTY LTD (1)
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7001329 Capsule endoscope guidance system, capsule endoscope holder, and capsule endoscope 30 2003
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7109933 Wearable jacket having communication function, and endoscope system employing wearable jacket 29 2005
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9579077 Multiple imaging mode tissue marker 0 2007
8401622 Biopsy marker with in situ-generated imaging properties 5 2007
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8670818 Marker delivery device for tissue marker placement 1 2008
8437834 Breast marker 7 2011
9042965 Biopsy marker with in situ-generated imaging properties 0 2013
D716450 Tissue marker for intracorporeal site identification 0 2013
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8086314 Devices and methods for cardiovascular reflex control 16 2002
7840271 Stimulus regimens for cardiovascular reflex control 70 2005
8290595 Method and apparatus for stimulation of baroreceptors in pulmonary artery 9 2006
8060206 Baroreflex modulation to gradually decrease blood pressure 21 2006
7813812 Baroreflex stimulator with integrated pressure sensor 40 2006
8838246 Devices and methods for cardiovascular reflex treatments 2 2006
8606359 System and method for sustained baroreflex stimulation 5 2007
7949400 Devices and methods for cardiovascular reflex control via coupled electrodes 16 2009
8583236 Devices and methods for cardiovascular reflex control 2 2010
8718789 Electrode structures and methods for their use in cardiovascular reflex control 3 2010
9044609 Electrode structures and methods for their use in cardiovascular reflex control 2 2011
8712531 Automatic baroreflex modulation responsive to adverse event 4 2012
8880190 Electrode structures and methods for their use in cardiovascular reflex control 2 2012
9427583 Electrode structures and methods for their use in cardiovascular reflex control 0 2015
 
Agentumcidalelectrics, Inc. (1)
8609036 Ex vivo antimicrobial devices and methods 3 2007
 
THE JOHNS HOPKINS UNIVERSITY (1)
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8612022 Neuromodulation catheters and associated systems and methods 0 2012
 
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7590454 Modular stimulation lead network 25 2004
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8412348 Intravascular self-anchoring integrated tubular electrode body 0 2004
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7937160 Methods for delivering cortical electrode leads into patient's head 4 2004
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BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (66)
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6735474 Implantable stimulator system and method for treatment of incontinence and pain 327 2000
6920359 Deep brain stimulation system for the treatment of Parkinson's Disease or other disorders 117 2001
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7054689 Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction 71 2001
6871099 Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain 226 2001
6941171 Implantable stimulator methods for treatment of incontinence and pain 163 2001
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* 7054692 Fixation device for implantable microdevices 111 2002
7860570 Implantable microstimulators and methods for unidirectional propagation of action potentials 149 2002
7292890 Vagus nerve stimulation via unidirectional propagation of action potentials 263 2002
7203548 Cavernous nerve stimulation via unidirectional propagation of action potentials 128 2002
* 2004/0015,205 Implantable microstimulators with programmable multielectrode configuration and uses thereof 235 2002
* 2003/0236,558 Vagus nerve stimulation via unidirectional propagation of action potentials 125 2002
* 2003/0236,557 Cavernous nerve stimulation via unidirectional propagation of action potentials 42 2002
7308303 Thrombolysis and chronic anticoagulation therapy 28 2002
* 2003/0083,698 Thrombolysis and chronic anticoagulation therapy 37 2002
7949395 Implantable microdevice with extended lead and remote electrode 116 2003
* 2003/0114,905 Implantable microdevice with extended lead and remote electrode 187 2003
* 2004/0162,590 Fully implantable miniature neurostimulator for intercostal nerve stimulation as a therapy for angina pectoris 127 2003
7539542 Lead connector, lead adapter, and lead insertion apparatus 8 2003
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7840279 Implantable microstimulator having a separate battery unit and methods of use thereof 5 2005
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* 7627383 Implantable stimulator 12 2005
* 2006/0212,087 Implantable stimulator 6 2005
7660631 Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction 9 2005
* 2005/0209,652 Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction 36 2005
7801600 Controlling charge flow in the electrical stimulation of tissue 17 2005
8175717 Ultracapacitor powered implantable pulse generator with dedicated power supply 24 2005
* 2007/0055,308 Ultracapacitor powered implantable pulse generator with dedicated power supply 47 2005
7729758 Magnetically coupled microstimulators 21 2005
7890177 Device and therapy for erectile dysfunction and other sexual dysfunction 1 2006
7865243 Device and therapy for erectile dysfunction and other sexual dysfunction 2 2006
8214048 Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction 13 2006
7801602 Controlling stimulation parameters of implanted tissue stimulators 15 2006
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8019441 Collapsible/expandable tubular electrode leads 0 2006
7899539 Cavernous nerve stimulation via unidirectional propagation of action potentials 23 2006
* 2007/0021,800 CAVERNOUS NERVE STIMULATION VIA UNIDIRECTIONAL PROPAGATION OF ACTION POTENTIALS 27 2006
7877136 Enhancement of neural signal transmission through damaged neural tissue via hyperpolarizing electrical stimulation current 68 2007
9248280 Closed-loop feedback for steering stimulation energy within tissue 0 2007
* 2009/0118,787 Closed-loop feedback for steering stimulation energy within tissue 27 2007
* 2009/0118,804 METHOD OF MOUNTING MINIMALLY INVASIVE PLUG ELECTRODES WITHIN CRANIUM OF PATIENT 12 2007
7783362 Vagus nerve stimulation via unidirectional propagation of action potentials 12 2007
7877137 Thrombolysis and chronic anticoagulation therapy 0 2007
* 2008/0286,327 THOMBOLYSIS AND CHRONIC ANTICOAGULATION THERAPY 2 2007
8355786 Lead connector, lead adapter, and lead insertion apparatus 3 2009
* 2009/0228,087 LEAD CONNECTOR, LEAD ADAPTER, AND LEAD INSERTION APPARATUS 2 2009
8185208 Modular stimulation lead network 1 2009
8060215 Implantable microstimulator having a battery unit and methods of use therefor 0 2010
9393421 Controlling charge flow in the electrical stimulation of tissue 3 2010
* 2010/0280,575 CONTROLLING CHARGE FLOW IN THE ELECTRICAL STIMULATION OF TISSUE 1 2010
* 2010/0280,572 OPEN LOOP DEEP BRAIN STIMULATION SYSTEM FOR THE TREATMENT OF PARKINSON'S DISEASE OR OTHER DISORDERS 1 2010
8548604 Implantable microstimulators and methods for unidirectional propagation of action potentials 1 2010
* 8655451 Telemetry system for use with microstimulator 12 2011
* 2011/0137,378 Telemetry System for Use With Microstimulator 8 2011
8712547 Cavernous nerve stimulation via unidirectional propagation of action potentials 0 2011
8032220 Method of implanting microdevice with extended lead and remote electrode 1 2011
* 2011/0172,679 METHOD OF IMPLANTING MICRODEVICE WITH EXTENDED LEAD AND REMOTE ELECTRODE 1 2011
8588917 Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction 17 2012
9409028 Implantable microstimulators with programmable multielectrode configuration and uses thereof 0 2012
9283394 Implantable microstimulators and methods for unidirectional propagation of action potentials 0 2013
9079041 Systems and methods for communicating with an implantable stimulator 0 2013
9242106 Telemetry system for use with microstimulator 3 2014
 
Navotek Medical Ltd. (1)
8164064 Localization of a radioactive source within a body of a subject 0 2010
 
SENORX, INC. (20)
* 2008/0294,039 Assembly with hemostatic and radiographically detectable pellets 20 2008
* 2010/0204,570 ANCHOR MARKERS 10 2010
* 8718745 Tissue site markers for in vivo imaging 2 2010
* 2010/0298,698 TISSUE SITE MARKERS FOR IN VIVO IMAGING 10 2010
8447386 Marker or filler forming fluid 0 2010
* 2011/0092,815 MARKER OR FILLER FORMING FLUID 8 2010
8361082 Marker delivery device with releasable plug 13 2011
* 2011/0166,448 MARKER DELIVERY DEVICE WITH RELEASABLE PLUG 0 2011
8498693 Intracorporeal marker and marker delivery device 0 2011
8626269 Fibrous marker and intracorporeal delivery thereof 10 2011
9149341 Deployment of polysaccharide markers for treating a site within a patient 1 2011
8668737 Tissue marking implant 4 2012
8784433 Plugged tip delivery tube for marker placement 1 2012
8626270 Cavity-filling biopsy site markers 12 2012
9044162 Marker delivery device with releasable plug 0 2013
8639315 Marker or filler forming fluid 8 2013
8880154 Fibrous marker and intracorporeal delivery thereof 0 2013
8965486 Cavity filling biopsy site markers 1 2013
9039763 Tissue marking implant 1 2014
9237937 Cavity-filling biopsy site markers 1 2015
* Cited By Examiner