Automated continuous and random access analytical system

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5358691
SERIAL NO

08126447

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
Abbott LaboratoriesABBOTT PARK, IL348

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Clark, Frederic L Plano, TX 14 877
Clift, Gilbert Mesquite, TX 10 674
Hendrick, Kendall B Southlake, TX 22 942
Kanewske, III William J Dallas, TX 14 892
Lagocki, Peter A Park Ridge, IL 11 683
Martin, Richard R Irving, TX 37 1421
Mitchell, James E Lake Barrington, IL 34 1046
Moore, Larry W Plano, TX 20 862
Pennington, Charles D Lake Zurich, IL 13 790
Smith, B Jane Vernon Hills, IL 11 780
Tayi, Apparao Grayslake, IL 12 913
Vaught, James A Euless, TX 11 715
Walker, Edna S Chicago, IL 9 673
Yost, David A Poolesville, MD 21 1039

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (6)
* 4314968 Simultaneous analysis apparatus 45 1980
* 4412973 Autonomous simultaneous analysis apparatus and a method of using it 40 1981
* 4470008 Capacitance sensor 45 1982
* 4766078 Automated consecutive reaction analyzer 37 1985
* 4687638 Device for detecting and quantifying agglutinates 30 1985
5096670 Automated patient sample analysis instrument 97 1989
 
Coulter Electronics, Inc. (4)
* 4276051 System and program for chemical reaction observation with a moving photometer 128 1980
* 4276260 Fluid transfer mechanism 60 1980
* 4326851 Level sensor apparatus and method 72 1980
* 4430299 Apparatus for monitoring chemical reactions 85 1981
 
Triton Biosciences, Inc. (1)
4984475 Ultra low carryover sample liquid analysis apparatus and method 29 1989
 
FUJIREBIO INC. (1)
5158895 Automatic immunological measuring system 135 1991
 
ENDRESS + HAUSER GMBH + CO. KG (1)
* 4449405 Rod-like probe for the capacitive measurement of the level in a container 49 1981
 
BEHRING DIAGNOSTICS GMBH (1)
5167922 Assay cartridge 63 1990
 
Japan Spectroscopic Co., Ltd. (1)
* 4429583 Liquid uptake and discharge apparatus 26 1982
 
HITACHI, LTD. (8)
* 4313735 Automatic chemical analyzing method and apparatus 136 1980
* 4451433 Automatic chemical analyzer 195 1981
* 4612289 Method for analyzing liquid sample 74 1981
5104808 Method and apparatus for effecting a plurality of assays on a plurality of samples in an automatic analytical device 149 1988
5051238 Automatic analyzing system 174 1988
5083283 Method of determining calibration curve and apparatus using calibaration curve 28 1989
4970468 Analytical equipment with function of detecting liquid surface capacitively 46 1989
5164318 Automatic enzyme immunoassay analyzer 41 1990
 
Technicon Instruments Corporation (1)
* 4629703 Automated analytical system 53 1983
 
THERMO INSTRUMENT SYSTEMS, INC. (1)
* 4836037 Sample metering valve for a sample preparation system 19 1987
 
Jencons (Scientific) Limited (1)
* 4815632 Liquid dosing device with digital display 54 1988
 
TOA MEDICAL ELECTRONICS CO., LTD. (1)
* 4495149 Optical-type automatic analyzing and measuring apparatus 91 1982
 
Pye (Electronic Products) Limited (1)
* 4302421 Method and apparatus for flushing a delivery tube for automatic liquid sample supply apparatus 33 1980
 
BLOCK, BARRY (1)
* 4584885 Capacitive detector for transducers 69 1984
 
CLINICAL DIAGNOSTIC SYSTEMS INC. (3)
* 4298571 Incubator including cover means for an analysis slide 141 1980
* 4794085 Apparatus and method for detecting liquid penetration by a container used for aspirating and dispensing the liquid 85 1987
5043143 Analyzer having humidity control apparatus 141 1990
 
KABUSHIKI KAISHA TOSHIBA (7)
* 4699766 Automatic chemical analyzer 100 1986
4908186 Automated chemical analyzer 88 1986
* 4808380 Automatic chemical analyzing apparatus 83 1987
* 4818492 Capacitive liquid level sensor for automatic chemical analyzer 77 1987
5049826 Liquid level sensing apparatus for use in automatic chemical analysis 39 1988
4906433 Automatic chemical analyzer 116 1989
5084242 Distribution nozzle apparatus for automatic chemical analyzer 104 1990
 
CIBA CORNING DIAGNOSTICS CORP. (1)
* 4737342 Test module 40 1982
 
MITUTOYO CORPORATION (2)
5049824 Phase discrimination type electrostatic capacity detector 23 1989
5053715 Capacitance-type measuring device for absolute measurement of positions 65 1990
 
SKF Industrial Trading and Development Company B.V. (1)
* 4471295 Device for detecting the variation of a capacitive impedance having dielectric consisting of a lubricant 25 1982
 
RAININ INSTRUMENT, LLC (1)
5187990 Method for dispensing liquids with a pipette with compensation for air pressure and surface tension 65 1992
 
BALDWYN, EINAR D.N. (1)
* 4836038 Automated sampler-injector apparatus and method for sampling a quantity of sample and testing portions of said quantity 78 1988
 
MITSUBISHI CHEMICAL CORPORATION (1)
4919887 Automatic analyzer 145 1988
 
E. I. DU PONT DE NEMOURS AND COMPANY (1)
5204264 Method for validation of calibration standards in an automatic chemical analyzer 79 1991
 
SCHIAPPARELLI BIOSYSTEMS, INC. (1)
4927765 Automatic reagent dispenser 32 1988
 
OLYMPUS OPTICAL CO., LTD. (24)
* 4311394 Automatic analytical apparatus 33 1980
* 4338279 Automatic analyzing apparatus 127 1980
* 4315891 Automatic analytical apparatus 89 1980
* 4406547 Apparatus for effecting automatic analysis 91 1980
* 4346056 Automatic analyzing apparatus 124 1980
* 4536369 Automatic analyzing apparatus 40 1981
* 4483927 Method of automatically analyzing chemical substances and an automatic chemical analyzer 107 1981
* 4472505 Method of analyzing chemical substances 43 1981
* 4448752 Liquid distributing device for use in chemical analyzer 30 1981
* 4456037 Process of delivering samples and reagents 46 1982
* 4502126 Apparatus for detecting an amount of liquid remained in a vessel 23 1982
* 4457893 Automated apparatus for photometrically detecting immunological agglutinating reactions 36 1982
* 4517160 Automatic analyzing apparatus 106 1983
* 4558946 Automatic analyzing apparatus 62 1983
* 4634576 Automatic analyzing apparatus 60 1983
* 4699767 Liquid transfer apparatus for automatic analyzers 74 1983
* 4781891 Automatic analyzing apparatus 137 1983
* 4540549 Chemical analyzing apparatus 43 1984
* 4837159 Method and apparatus for effecting immunological analysis 81 1985
5175086 Method for effecting heterogeneous immunological analysis 62 1987
* 4844887 Automatic analyzing apparatus 70 1987
4971913 Method for controlling reagent delivery system in automatic chemical analyzer 54 1987
* 4826319 Method and apparatus for measuring immunological reaction with the aid of fluctuation in intensity of scattered light 40 1988
5045286 Device for aspirating a fixed quantity of liquid 56 1989
 
LIONHEART TECHNOLOGIES, INC. (2)
4926701 Pipetting method and apparatus 40 1989
5035150 Pipetting method 24 1990
 
VENTURE MEASUREMENT COMPANY LLC (3)
* 4499766 Capacitance-type material level indicator 41 1982
* 4555941 Capacitance-type material level indicator 47 1984
* 4676100 Capacitance-type material level indicator 61 1986
 
Le Materiel Biomedical (1)
* 4575492 Process and device for the detection and quantification of agglutinates 24 1984
 
ROBERT BOSCH GMBH (1)
4926150 Electromagnetic relay 19 1989
 
RHONE POULENC RECHERCHES, 25, QUAI PAUL DOUMER- 92408 COURBEVOIE CEDEX (FRANCE) (1)
* 4805469 Apparatus for automatically taking and analyzing samples of substances which are made available in random manner 39 1987
 
PHARMACIA DIAGNOSTICS INC. (1)
* 4459265 Automatically operating analysis apparatus 115 1981
 
KABUSHIKI KAISHA TIYODA SEISAKUSHO (1)
5167926 Apparatus for pretreating cells for flow cytometry 96 1990
 
Chromacol Limited (1)
5116578 Vial sleeve 32 1987
 
JAPAN TECTRON INSTRUMENTS CORPORATION (1)
* 4774055 Automatic analysis apparatus 201 1986
 
Japan Tectron Instruments Corporation Tokuyama Soda Kabushiki Kaisha (1)
* 4647432 Automatic analysis apparatus 173 1983
 
MOCHIDA PHARMACEUTICAL CO., LTD. (1)
5158748 Automated dispensing and diluting system 65 1991
 
DIONEX CORPORATION (1)
* 4644807 Fluid sample delivery apparatus 64 1985
 
CETUS CORPORATION (1)
* 4586546 Liquid handling device and method 108 1984
 
BECEEM COMMUNICATIONS, INC. (3)
5087423 Automatic analyzing apparatus comprising a plurality of analyzing modules 70 1989
5213761 Automatic chemical analyzer having an improved delivery mechanism 69 1990
5192505 Automatic analyzing apparatus 73 1990
 
P.M. America, Inc. (1)
* 4346742 Method for diluting a liquid test sample and computer controlld diluting apparatus 35 1980
 
TELEFLEX INCORPORATED (1)
5005409 Capacitive liquid sensor 37 1990
 
IL HOLDING S.P.A. (4)
* 4738825 Cuvette handling 54 1985
* 4764342 Reagent handling 163 1985
* 4788150 Liquid handling 35 1987
4961906 Liquid handling 129 1988
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
4864169 Polyphase variable reluctance motor 25 1986
 
Beckman Instruments, Inc. (8)
* 4736638 Liquid level sensor 61 1987
4908320 Analyzer operating method 98 1989
4965049 Modular analyzer system 179 1989
4900513 Sample loading apparatus 68 1989
5104621 Automated multi-purpose analytical chemistry processing center and laboratory work station 204 1989
4970053 Reagent cartridge 52 1989
5108703 Automated multi-purpose analytical chemistry processing center and laboratory work station 114 1991
5204269 Sample handling for chemistry analyzers 22 1992
 
I.E. HARDELEC AG (1)
* 4526046 Method and apparatus for transferring a liquid sample 42 1983
 
Kabushiki Kaisha Kyoto Daiichi Kagaku (1)
4876204 Method and apparatus of automatic continuous analysis using analytical implement 55 1985
 
Monitor Technologies, LLC (1)
4914377 Radio frequency capacitance probe system for material detection 22 1988
 
Costar Corporation (1)
5104624 Pipetter 55 1991
 
LABSYTEMS OY, HELSINKI, FINLAND, PUTTITIE 9, (1)
* 4554134 Pipette with adjustable volume 30 1984
 
MILES INC. (1)
5137693 Spring biased test tube holder 76 1990
 
SEAGATE TECHNOLOGY LLC (1)
5136250 Capacitance height gauge 32 1990
 
KAVLICO, KAVLICO, A CORP. OF CA (1)
4924702 Liquid level sensor 42 1989
 
NOVA BIOMEDICAL CORPORATION (1)
5027075 Apparatus for determination of probe contact with a liquid surface 44 1989
 
Konica Corporation (1)
5049359 Apparatus for biochemical analysis 50 1990
 
BECTON, DICKINSON AND COMPANY (2)
* 4678752 Automatic random access analyzer 271 1985
* 4826660 Detector assembly for analyzer instrument 107 1987
 
DADE BEHRING INC. (1)
* 4595562 Loading and transfer assembly for chemical analyzer 144 1983
 
DADE BEHRING MARBURG GMBH (1)
5141871 Fluid dispensing system with optical locator 104 1990
 
Bio/Data Corporation (1)
* 4695430 Analytical apparatus 162 1985
 
TOSOH CORPORATION (2)
* 4821080 Measuring apparatus for enzyme reaction rates 21 1988
5178834 Automatic immunoassay analyzer 54 1992
 
IMI CORNELIUS, INC. (1)
5057823 Probe for sensing the presence of liquid in a container 18 1990
 
IWASAKI ELECTRIC CO., LTD. (1)
* 4568873 Easy-to-assemble capacitive probe for a high precision dimensional or distance gage 35 1983
 
MITSUBISHI KASEI CORPORATION (1)
* 4834944 Automatic analytical apparatus 76 1987
 
BAXTER INTERNATIONAL INC. (1)
* 4679446 Multi-volume displacement pipette 53 1985
 
EASTMAN KODAK COMPANY (1)
5114679 Method of using a pipette 26 1990
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (3)
4977786 Capacitive liquid level sensor 61 1990
5012683 Capacitive liquid interface sensor 33 1990
5101673 Ultra low sample liquid analysis apparatus and method 29 1991
 
SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH (1)
5149654 Incubation device for microtiter plates 62 1990
 
LIFESHIELD SCIENCES LLC (1)
* 2004/0158,312 Braided endoluminal device having tapered filaments 25 2003
 
KABUSHIKI KAISHA NITTEC (1)
* 4731225 Automatic analysis apparatus 120 1986
 
AGILENT TECHNOLOGIES, INC. (1)
4863695 Pipette assembly 55 1987
 
Flow Laboratories Limited (1)
5063790 Pipette tip pickup apparatus 40 1989
 
Boehringer Mannheim GmbH (1)
* 4515889 Method for carrying out analytical determinations 99 1981
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (17)
* 2002/0031,837 Handling method of body fluid sample and analysis apparatus using the same 13 2001
* 2002/0106,803 Handling method of body fluid sample and analysis apparatus using the same 0 2002
* 2002/0151,085 Guided deposition in spatial arrays 11 2002
* 2002/0119,578 Guided deposition in spatial arrays 22 2002
* 2004/0185,464 High throughput assay system 6 2003
* 2005/0239,097 High throughput assay system using mass spectrometry 0 2004
* 2009/0155,923 Photometric Measuring Method for a Sample Liquid, A Photometric Measuring Device, and a Mixing Container for a Photometric Measuring Device 6 2006
* 2009/0047,179 AUTOMATED SAMPLE PROCESSING SYSTEM 25 2008
* 2010/0105,572 HIGH THROUGHPUT ASSAY SYSTEM 2 2008
7932369 Diagnostic test for vitamin B.sub.12 0 2009
10001497 Diagnostic analyzers with pretreatment carousels and related methods 0 2013
10022372 Caveolin-1 related methods for treating glioblastoma with temozolomide 0 2014
9987414 System for delivery of fluids such as ammonia nitrogen 13 0 2015
10006023 Phage microarray profiling of the humoral response to disease 0 2016
9987357 Methods and monitoring of treatment with a WNT pathway inhibitor 0 2016
10036715 Automatic isothermal titration microcalorimeter apparatus and method of use 0 2016
10006862 Continuous process for performing multiple nucleic acid amplification assays 0 2017
 
NEOGEN CORPORATION (2)
* 6927851 Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods 26 2001
* 2001/0038,450 Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods 41 2001
 
ARMUNE BIOSCIENCES, INC. (2)
* 2011/0237,461 USING PHAGE EPITOPES TO PROFILE THE IMMUNE RESPONSE 3 2011
9658231 Using phage epitopes to profile the immune response 0 2015
 
LSI MEDIENCE CORPORATION (1)
8409872 Cartridge for automatic measurement and measuring method using it 0 2002
 
HITACHI, LTD. (4)
* 5628962 Apparatus for opening and closing reagent containers 37 1995
* 7105351 Handling method of body fluid sample and analysis apparatus using the same 5 2002
* 6924152 Handling method of body fluid sample and analysis apparatus using the same 9 2002
* 2005/0287,039 Handling method of body fluid sample and analysis apparatus using the same 1 2005
 
VENTANA MEDICAL SYSTEMS, INC. (10)
* 6594537 Automated tissue assay using standardized chemicals and packages 85 1998
7270785 Automated molecular pathology apparatus having fixed slide platforms 36 2002
7303725 Automated high volume slide staining system 59 2003
7378055 Automated molecular pathology apparatus having fixed slide platforms 51 2003
7468161 Automated high volume slide processing system 40 2005
8663991 Automated high volume slide processing system 1 2005
* 7404927 Automated molecular pathology apparatus having fixed slide platforms 32 2005
8048373 Automated high volume slide staining system 4 2007
* 7935534 Automated molecular pathology apparatus having fixed slide platforms 4 2010
9528918 Automated high volume slide processing system 0 2013
 
HTG MOLECULAR DIAGNOSTICS, INC. (1)
7659063 High throughput assay system 2 2004
 
AKZO NOBEL N.V. (1)
* 6110428 Device for use in the isolation of a biological material such as nucleic acid 7 1997
 
GEN-PROBE INCORPORATED (47)
6605213 Method and apparatus for performing a magnetic separation purification procedure on a sample solution 139 2000
6764649 Transport mechanism 81 2001
7033820 Automated system for isolating and amplifying a target nucleic acid sequence 45 2001
6890742 Automated process for isolating and amplifying a target nucleic acid sequence 107 2001
7267795 Incubator for use in an automated diagnostic analyzer 62 2002
7135145 Device for agitating the fluid contents of a container 43 2002
7118892 Automated process for preparing and amplifying a target nucleic acid sequence 46 2002
7384600 Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer 14 2002
7396509 Instrument for detecting light emitted by the contents of a reaction receptacle 16 2003
7560255 Automated process for detecting the presence of a target nucleic acid in a sample 40 2004
7666681 Method for agitating the fluid contents of a container 20 2005
7560256 Automated process for detecting the presence of a target nucleic acid in a sample 32 2005
7524652 Automated process for detecting the presence of a target nucleic acid in a sample 33 2005
7482143 Automated process for detecting the presence of a target nucleic acid in a sample 33 2005
8615368 Method for determining the amount of an analyte in a sample 9 2006
8008066 System for performing multi-formatted assays 51 2006
7964413 Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay 29 2006
7932081 Signal measuring system for conducting real-time amplification assays 10 2006
7897337 Method for performing multi-formatted assays 16 2006
7794659 Signal measuring system having a movable signal measuring device 11 2006
7547516 Method for reducing the presence of amplification inhibitors in a reaction receptacle 2 2006
8012419 Temperature-controlled incubator having rotatable door 7 2007
8137620 Temperature-controlled incubator having an arcuate closure panel 4 2007
* 9598723 Automated analyzer for performing a nucleic acid-based assay 0 2007
* 2008/0268,528 Automated analyzer for use in performing nucleic Acid-based amplification reactions 37 2007
8337753 Temperature-controlled incubator having a receptacle mixing mechanism 3 2007
8318500 Method for agitating the contents of a reaction receptacle within a temperature-controlled environment 4 2007
8192992 System and method for incubating the contents of a reaction receptacle 20 2007
7666602 Method for agitating the fluid contents of a container 25 2007
8309358 Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment 3 2007
7638337 System for agitating the fluid contents of a container 7 2007
8569019 Method for performing an assay with a nucleic acid present in a specimen 1 2007
8569020 Method for simultaneously performing multiple amplification reactions 2 2008
8546110 Method for detecting the presence of a nucleic acid in a sample 1 2008
8440429 Method for detecting the presence of a nucleic acid in a sample 0 2008
8501461 System for performing multi-formatted assays 15 2009
8663922 Systems and methods for detecting multiple optical signals 2 2010
8349564 Method for continuous mode processing of the contents of multiple reaction receptacles in a real-time amplification assay 16 2010
9372156 System for processing contents of a receptacle to detect an optical signal emitted by the contents 1 2011
9046507 Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure 0 2011
8221682 System for incubating the contents of a reaction receptacle 3 2011
8718948 Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector 1 2012
8709814 Method for incubating the contents of a receptacle 0 2012
8883455 Method for detecting the presence of a nucleic acid in a sample 1 2013
9726607 Systems and methods for detecting multiple optical signals 0 2014
9915613 Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector 0 2014
9150908 Method for detecting the presence of a nucleic acid in a sample 1 2014
 
ABBOTT MOLECULAR INC. (2)
* 9114392 Apparatus and method for handling fluids for analysis 1 2012
* 2013/0065,315 Apparatus and Method for Handling Fluids for Analysis 2 2012
 
ORTHO-CLINICAL DIAGNOSTICS, INC. (6)
7250303 Chemistry system for a clinical analyzer 19 2002
8606525 Determining useful life of a fluid using inventory information 1 2005
* 2008/0020,469 METHOD FOR SCHEDULING SAMPLES IN A COMBINATIONAL CLINICAL ANALYZER 4 2007
* 2008/0020,467 FLUID METERING IN A METERING ZONE 8 2007
7855084 Chemistry system for clinical analyzer 11 2007
* 2008/0145,939 Chemistry system for clinical analyzer 11 2007
 
NODALITY, INC. (6)
* 2009/0269,800 DEVICE AND METHOD FOR PROCESSING CELL SAMPLES 18 2009
* 2010/0042,351 METHODS AND APPARATUS RELATED TO MANAGEMENT OF EXPERIMENTS 24 2009
* 2010/0014,741 METHODS AND APPARATUS RELATED TO GATE BOUNDARIES WITHIN A DATA SPACE 18 2009
* 2010/0030,719 METHODS AND APPARATUS RELATED TO BIOINFORMATICS DATA ANALYSIS 16 2009
9034257 High throughput flow cytometry system and method 4 2009
9183237 Methods and apparatus related to gate boundaries within a data space 1 2012
 
STONY BROOK ANESTHESIOLOGY, UNIVERSITY FACULTY PRACTICE CORPORATION (1)
* 2007/0003,992 Methods and kits for detecting cerebrospinal fluid in a sample 17 2006
 
IRORI TECHNOLOGIES, INC. (2)
6017496 Matrices with memories and uses thereof 177 1996
6329139 Automated sorting system for matrices with memory 268 1997
 
HAMILTON BONADUZ AG (1)
9764870 Device for the automated opening of flip tubes 0 2011
 
Stony Brook Anaesthesiology, Univeristy Faculty Practice Corporation (3)
7794953 Method and kits for detecting cerebrospinal fluid in a sample 1 2007
8003765 Methods, antibodies and kits for detecting cerebrospinal fluid in a sample 0 2008
* 2008/0227,113 Methods, Antibodies and Kits for Detecting Cerebrospinal Fluid in a Sample 5 2008
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
9907833 Use of relaxin to treat placental syndromes 0 2014
 
CANON KABUSHIKI KAISHA (1)
* 2007/0077,174 Nucleic acid sample testing apparatus 1 2006
 
ILLUMINA, INC. (4)
7612020 Composite arrays utilizing microspheres with a hybridization chamber 23 2004
7510841 Methods of making and using composite arrays for the detection of a plurality of target analytes 12 2004
8628952 Array kits and processing systems 2 2009
7901897 Methods of making arrays 3 2009
 
TOSHIBA MEDICAL SYSTEMS CORPORATION (3)
* 2006/0120,922 Analyzer, lid device, and reagent storing device 9 2006
9400285 Automated diagnostic analyzers having vertically arranged carousels and related methods 0 2014
9335338 Automated diagnostic analyzers having rear accessible track systems and related methods 1 2014
 
MALVERN INSTRUMENTS INCORPORATED (1)
9404876 Automatic isothermal titration microcalorimeter apparatus and method of use 0 2015
 
Helena Laboratories Corporation (1)
* 5879628 Blood coagulation system having a bar code reader and a detecting means for detecting the presence of reagents in the cuvette 27 1997
 
ABBOTT LABORATORIES (9)
* 5616460 Buffer composition for reagents for immunoassay 10 1995
* 5812419 Fully automated analysis method with optical system for blood cell analyzer 57 1995
7445933 Stable calibrators or controls for measuring human natriuretic peptides 1 2003
* 2005/0014,287 Stable calibrators or controls for measuring human natriuretic peptides 8 2003
7291501 Stable compositions for measuring human natriuretic peptides 1 2003
* 2005/0014,289 Stable compositions for measuring human natriuretic peptides 7 2003
* 2009/0181,359 METHOD OF PERFORMING ULTRA-SENSITIVE IMMUNOASSAYS 9 2007
8222048 Automated analyzer for clinical laboratory 6 2008
* 2009/0117,620 AUTOMATED ANALYZER FOR CLINICAL LABORATORY 51 2008
 
Biospectra AG (1)
* 2008/0095,676 Multiple Bio-Reactor Device 1 2005
 
ONCOMED PHARMACEUTICALS, INC. (14)
9850311 Compositions and methods for diagnosing and treating cancer 0 2006
8324361 Nucleic acid molecules encoding soluble frizzled (FZD) receptors 2 2010
9157904 Wnt antagonists and methods of treatment and screening 5 2011
8507442 Methods of use for an antibody against human frizzled receptors 1, 2. 5, 7 or 8 16 2011
8765913 Human frizzled (FZD) receptor polypeptides and methods of use thereof for treating cancer and inhibiting growth of tumor cells 1 2012
9273139 Monoclonal antibodies against frizzled 4 2013
8975044 Polynucleotides encoding for frizzled-binding agents and uses thereof 0 2013
9499630 Frizzled-binding agents and uses thereof 0 2013
9266959 Methods of treating neuroendocrine tumors using frizzled-binding agents 4 2013
9359444 Methods and monitoring of treatment with a Wnt pathway inhibitor 0 2014
9168300 MET-binding agents and uses thereof 1 2014
9573998 Antibodies against human FZD5 and FZD8 0 2015
9579361 Wnt antagonist and methods of treatment and screening 0 2015
9732139 Methods of treating cancer by administering a soluble receptor comprising a human Fc domain and the Fri domain from human frizzled receptor 0 2015
 
MONOGEN, INC. (2)
* 2006/0120,835 Article handling system and method 8 2005
* 2006/0120,834 Article handling system and method 7 2005
 
INSTRUMENTATION LABORATORY COMPANY (5)
* 2003/0087,447 Sample well strip 1 2001
D481133 Sample well-strip for an automated sample analyzer 14 2002
7927876 Sample well strip and method of use 0 2010
8802037 Sample well strip 0 2011
* 2011/0152,129 SAMPLE WELL STRIP 0 2011
 
DUKE UNIVERSITY (1)
* 2010/0179,067 SERUM BIOMARKERS FOR THE EARLY DETECTION OF LUNG CANCER 1 2008
 
HIGH THROUGHPUT GENOMICS, INC. (1)
* 2003/0039,967 High throughput assay system using mass spectrometry 1 2001
 
Erickson, Jeffrey P. (1)
9056114 Chemical induction of lactation 1 2010
 
Abbott Laboratories (8)
* 5773212 Buffer composition for reagents for immunoassay 5 1996
* 6159750 Fluorescence polarization immunoassay diagnostic method 60 1997
7351586 Method of making stable calibrators or controls for measuring human natriuretic peptides 4 2005
* 2008/0241,832 METHOD OF DETECTING AND QUANTIFYING HEPATITIS C VIRUS 0 2007
7674623 Method of stabilizing human natriuretic peptides 0 2007
* 2008/0248,579 Method of stabilizing human natriuretic peptides 0 2007
* 2011/0171,648 METHOD OF DETECTING AND QUANTIFYING HEPATITIS C VIRUS 0 2011
9329194 Automated analyzer for clinical laboratory 1 2012
 
HOLOGIC, INC. (1)
6974294 Article handling system and method 24 2002
 
TOYO BOSEKI KABUSHIKI KAISHA (1)
* 5538849 Apparatus for automated assay of DNA probe and method for assaying nucleic acid in sample 110 1993
 
High Throughput Genomics (1)
7413852 Multiplexed diagnostic and therapeutics 6 2002
 
BIO-CHEM LABORATORY SYSTEMS, INC. (1)
* 5730938 Chemistry analyzer 96 1995
 
BECEEM COMMUNICATIONS, INC. (5)
* 6060022 Automated sample processing system including automatic centrifuge device 192 1997
6793888 Method and system for sample aliquot storage 5 2001
RE46214 Method and system for sample aliquot storage 0 2006
8038942 Automated sample processing system 8 2008
* 9910054 System and method for processing samples 0 2012
 
BIOMERIEUX, INC. (11)
D377455 Automatic sample testing machine 24 1996
* 5762873 Automatic sample testing machine 107 1996
* 5955736 Reflector assembly for fluorescence detection system 6 1997
* 5925884 Fluorescence station for biological sample testing machine 11 1997
* 5853666 Optical reader and sample card transport stations for biological sample testing machine 27 1997
* 5856193 Automatic sample testing method 10 1997
* 5888455 Optical reader and sample card transport stations for biological sample testing machine 17 1997
* 5798085 Optical reader and sample card transport stations for biological sample testing machine 31 1997
* 5965090 Vacuum loading of test sample cards in an analytical instrument 19 1998
* 5891396 Cutting and sealing station for test sample cards in an automated analytical system 15 1998
* 6086824 Automatic sample testing machine 43 1999
 
The General Hospitall Corporation (1)
8574832 Methods for preparing sequencing libraries 0 2010
 
EXXONMOBIL CHEMICAL PATENTS INC. (2)
7435598 Catalyst testing apparatus and process 5 2003
* 2005/0101,022 Catalyst testing apparatus and process 0 2003
 
ARKRAY, INC. (2)
* 8940231 Measuring equipment and measuring method using cartridge container, and program recording medium 2 2007
* 2007/0148,052 Measuring equipment and measuring method using cartridge container, and program recording medium 6 2007
 
FREESLATE, INC. (1)
* 2002/0110,925 Apparatus and method for testing compositions in contact with a porous medium 0 2002
 
Lachat Instruments (1)
* 5492831 Shared peripheral analytical system 21 1994
 
Biokit, S.A. (2)
8480954 Apparatus and methods for dispensing sample holders 12 2010
9523699 Apparatus and methods for dispensing sample holders 0 2013
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (4)
8481698 Parallel proximity ligation event analysis 0 2009
* 2010/0240,101 Parallel Proximity Ligation Event Analysis 7 2009
* 2011/0189,677 Methods For Preparing Sequencing Libraries 1 2010
9125931 Post-transcriptional regulation of RNA-related processes using encoded protein-binding RNA aptamers 0 2010
 
Johnson & Johnson Clinical Diagnostics, Inc. (1)
* 5518693 Transfer mechanism for automatic loading and unloading of reagent modules 21 1994
 
F. HOFFMANN-LA ROCHE AG (2)
* 8703056 Automated analyzer and device for opening/closing the lids of reagent vessels 2 2010
* 2012/0328,475 AUTOMATIC ANALYZING DEVICE AND DEVICE FOR OPENING AND CLOSING COVER OF REAGENT CONTAINER THEREIN 2 2010
 
RENOVAR INCORPORATED (1)
* 2011/0236,912 SYSTEMS AND METHODS FOR CHARACTERIZING LUPUS ERYTHEMATOSUS 0 2009
 
BIOVERIS CORPORATION (1)
* 2007/0116,600 Detection device and methods associated therewith 68 2006
 
INVERNESS MEDICAL - BIOSTAR INC. (1)
6656428 Automated point of care detection system including complete sample processing capabilities 162 2000
 
APPLIED BIOSYSTEMS, LLC (1)
* 2004/0241,659 Apparatus and method for hybridization and SPR detection 1 2003
 
FUJITSU SEMICONDUCTOR LIMITED (1)
* 2009/0045,451 Semiconductor device and method of manufacturing the same 1 2008
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (26)
9492538 Isolation and use of solid tumor stem cells 0 2005
* 2006/0073,125 Isolation and use of solid tumor stem cells 36 2005
* 2006/0051,325 Isolation and use of solid tumor stem cells 19 2005
* 2007/0099,209 Compositions and methods for treating and diagnosing cancer 48 2006
7850961 Methods for targeting solid tumor stem cells in a solid tumor using a notch4 receptor antagonist 22 2006
8652467 Dek protein compositions and methods of using the same 0 2006
* 2009/0004,197 Dek Protein Compositions and Methods of Using the Same 5 2006
7723112 Compositions and methods for treating and diagnosing cancer 16 2006
* 2008/0064,049 Compositions and methods for treating and diagnosing cancer 43 2006
* 2007/0212,737 Isolation and use of solid tumor stem cells 31 2006
7713710 Isolation and use of solid tumor stem cells 19 2007
8044259 Determining the capability of a test compound to affect solid tumor stem cells 3 2007
8148147 Compositions and methods for treating and diagnosing pancreatic cancer 2 2008
* 2008/0261,244 Compositions And Methods For Treating And Diagnosing Pancreatic Cancer 6 2008
* 2008/0292,546 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 13 2008
* 2008/0260,734 COMPOSITIONS AND METHODS FOR CHARACTERIZING, REGULATING, DIAGNOSING, AND TREATING CANCER 21 2008
* 2011/0092,452 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PANCREATIC CANCER 1 2009
7939263 Compositions and methods for treating and diagnosing cancer 4 2009
* 2011/0033,481 PROSPECTIVE IDENTIFICATION AND CHARACTERIZATION OF BREAST CANCER STEM CELLS 18 2010
9267133 Phage microarray profiling of the humoral response to disease 2 2010
* 2011/0092,378 ISOLATION AND USE OF SOLID TUMOR STEM CELLS 18 2010
* 2011/0183,866 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 9 2011
8420885 Determining the capability of a test compound to affect solid tumor stem cells 1 2011
8501472 Compositions and methods for treating and diagnosing pancreatic cancer 0 2012
9327023 HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells 0 2012
9089556 Method for treating cancer using an antibody that inhibits notch4 signaling 0 2013
 
INOVA DIAGNOSTICS, INC. (2)
7745146 Compositions and methods for diagnosing patients with acute atherosclerotic syndrome 2 2007
7622268 Methods and assays for detecting GP73-specific autoantibodies 0 2007
 
AFFINIMARK TECHNOLOGIES, INC., (3)
8445218 Device and methods for the immunological identification of cerebrospinal fluid 3 2010
9347955 Device and methods for the immunological identification of cerebrospinal fluid 0 2013
9310382 Device and methods for the immunological identification of cerebrospinal fluid 0 2014
 
AFFYMETRIX, INC. (16)
* 6121048 Method of conducting a plurality of reactions 110 1994
6399365 Bioarray chip reaction apparatus and its manufacture 91 2001
6551817 Method and apparatus for hybridization 60 2002
6733977 Hybridization device and method 38 2002
* 2004/0106,130 Bioarray chip reaction apparatus and its manufacture 36 2003
7364895 Bioarray chip reaction apparatus and its manufacture 3 2003
* 2004/0166,525 Bioarray chip reaction apparatus and its manufacture 16 2004
* 2004/0171,054 Bioarray chip reaction apparatus and its manufacture 8 2004
* 2004/0235,033 Guided deposition in spatial arrays 1 2004
* 2005/0158,819 Bioarray chip reaction apparatus and its manufacture 17 2004
* 2005/0106,615 Bioarray chip reaction apparatus and its manufacture 9 2004
* 2005/0208,646 Bioarray chip reaction apparatus and its manufacture 9 2004
* 2005/0106,617 Bioarray chip reaction apparatus and its manufacture 11 2004
* 2005/0089,953 Bioarray chip reaction apparatus and its manufacture 8 2004
* 2005/0181,403 Methods for making a device for concurrently processing multiple biological chip assays 7 2005
8796186 System and method for processing large number of biological microarrays 21 2009
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (1)
* 2012/0156,113 FLUIDIC SYSTEMS, FLUID CONTAINERS AND PROCESSES FOR WASHING FLUID LINES 0 2011
 
THE GENERAL HOSPITAL CORPORATION (1)
* 2011/0183,434 DIAGNOSTIC METHODS AND KITS USING FIBROBLAST GROWTH FACTOR-23 0 2009
 
Bio/Data Corporation (5)
6398956 Method and apparatus for directly sampling a fluid for microfiltration 76 2000
6740240 Method and apparatus for directly sampling a fluid for microfiltration 29 2002
6926834 Method and apparatus for directly sampling a fluid for microfiltration 14 2004
* 2004/0217,059 Method and apparatus for directly sampling a fluid for microfiltration 2 2004
7288195 Method and apparatus for directly sampling a fluid for microfiltration 7 2005
 
TOSOH CORPORATION (2)
7700042 Automated analyzer 4 2004
* 2004/0265,173 Automated analyzer 15 2004
 
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (1)
8889361 Gene expression signatures in enriched tumor cell samples 1 2008
 
OncoMed Pharmaceuticals (2)
8551789 Frizzled-binding agents and their use in screening for WNT inhibitors 16 2011
9228013 Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell 2 2014
 
HITACHI HIGH-TECHNOLOGIES CORPORATION (2)
* 9466040 Automatic analysis system and device management server 0 2011
* 2013/0117,042 AUTOMATIC ANALYSIS SYSTEM AND DEVICE MANAGEMENT SERVER 3 2011
 
UNIVERSITY OF MASSACHUSETTS (2)
7794951 SREBP2gc transcription factors and uses thereof 0 2005
* 2007/0089,179 SREBP2gc transcription factors and uses thereof 0 2005
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (8)
* 5717148 Analysis instrument having carrier with liquid receiving wells 13 1996
6374982 Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics 20 2000
6332636 Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics 14 2000
6293750 Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics 72 2000
* 6498037 Method of handling reagents in a random access protocol 56 2000
7182912 Fluid handling apparatus for an automated analyzer 17 2002
* 7670553 Carousel system for automated chemical or biological analyzers employing linear racks 14 2005
* 2006/0245,865 Carousel system for automated chemical or biological analyzers employing linear racks 4 2005
 
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (5)
8362318 Enzyme directed oil biosynthesis in microalgae 3 2009
* 2010/0192,258 Enzyme Directed Oil Biosynthesis In Microalgae 3 2009
9328335 (burning bush) 1 2010
9062331 Enzyme directed oil biosynthesis in microalgae 2 2012
9771605 Enzyme directed oil biosynthesis in microalgae 0 2015
 
PENTYALA, SRINIVAS N. (1)
* 2004/0203,079 Methods and kits for detecting cerebrospinal fluid in a sample 4 2003
* Cited By Examiner