Sequence specific DNA binding by p53

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United States of America Patent

PATENT NO 5362623
SERIAL NO

07860758

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Abstract

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Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.

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Patent Owner(s)

Patent OwnerAddress
PHARMAGENICS INC4 PEARL COURT ALLENDALE NJ 07401

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kinzler, Kenneth W Baltimore, MD 296 5437
Sherman, Michael I Glen Ridge, NJ 26 648
Vogelstein, Bert Baltimore, MD 338 7135

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