Composition and method for acceleration of clot lysis

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United States of America Patent

PATENT NO 5372812
SERIAL NO

07943372

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a novel treatment for blood clots within a patient or myocardial infarction which comprises administering a hapten-binding molecule capable of preventing inhibition of plasmin by endogenous alpha-2-antiplasmin. The invention also relates to a treatment for blood clots within a patient or myocardial infarction comprising coadministrating the hapten-binding molecule of the invention together with a thrombolytic agent capable of either dissolving fibrin-platelet clots or inhibiting their formation. The therapy of the invention is capable of increasing clot lysis while minimizing fibrinogen breakdown and preventing the reocclusion of the affected coronary artery. The therapy of the present invention is capable of achieving this goal even in the absence of heparin and when the concentration of thrombolytic agent is lower than that required by other potential therapies.

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Patent Owner(s)

Patent OwnerAddress
THE GENERAL HOSPITAL CORPORATION55 FRUIT STREET BOSTON MA 02114 02114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Haber, Edgar New York, NY 34 487
Matsueda, Gary R Princeton, NJ 18 199
Reed, Guy L Cambridge, MA 25 80

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