Methods for the synthesis of monofucosylated oligosaccharides terminating in di-N-acetyllactosaminyl structures
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United States of America Patent
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Dec 20, 1994
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N/A
app pub date -
Jul 14, 1992
filing date -
Jun 10, 1991
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Abstract
Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound .beta.Gal(1-4).beta.GlcNAc(1-3).beta.Gal(1-4).beta.GlcNAc-OR. In particular, the methods of this invention provide for a multi-step synthesis wherein selective monofucosylation is accomplished on the 3-hydroxy group on only one of the GlcNAc units found in the .beta.Gal(1-4) .beta.GlcNAc (1-3) .beta.Gal (1-4) .beta.GlcNAc-OR compound. In this step, monofucosylation is achieved by use of the .alpha.(1-3)fucosyltransferase.
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